Let’s format the names

data_all  <- data_all  %>% 
    mutate(name = gsub('_flipped', '', name),
           name = gsub('_rc', '', name))
data_all <- data_all %>% 
    mutate(category = case_when(grepl('unscrambled', .$name) ~ 'unscramble',
                                grepl('neg', .$name) ~ 'negative',
                                TRUE ~ 'scramble'))
table(data_all$category)

  negative   scramble unscramble 
       553      51702       1796 
data <- filter(data_all, category != 'negative')
data <- data %>% 
    separate(name, into = c('tss_name', 'tss_position', 'strand_scramble_loc'), sep = ',',
             convert = T, remove = F) %>% 
    separate(strand_scramble_loc, into = c('strand', 'scramble_loc'), sep = '_') %>% 
    mutate(scramble_loc = gsub('unscrambled', NA, scramble_loc),
           scramble_loc = gsub('scrambled', '', scramble_loc)) %>% 
    separate(scramble_loc, into = c('scramble_start', 'scramble_end'),
             sep = '-', convert = T)
Expected 3 pieces. Missing pieces filled with `NA` in 6 rows [12856, 12912, 14805, 38073, 42258, 46862].
example <- filter(data, tss_name == 'TSS_2716_regulondb')
ggplot(example, aes(scramble_start, RNA_exp_ave)) + geom_point()+
    labs(x = 'scramble start position (length 10bp)', y = 'expression')

negatives <- filter(data_all, category == 'negative')
neg_median <- median(negatives$RNA_exp_ave)
threshold <- 2 * neg_median
example <- example %>% 
    mutate(active = ifelse(RNA_exp_ave >= threshold, 'active', 'inactive'))
ggplot(example, aes(scramble_start, RNA_exp_ave)) + geom_point(aes(color = active)) +
    scale_color_manual(values = c('red', 'black')) +
    labs(x = 'scramble start position (length 10bp)', y = 'expression', color = '')

ggplot(data, aes(scramble_start, RNA_exp_ave)) + geom_point() +
    labs(x = 'scramble start position (length 10bp)', 'expression') +
    scale_y_log10()

Let’s calculate the expression of each scrambled sequence relative to the unscrambled sequence

data <- data %>% 
    group_by(tss_name) %>% 
    mutate(unscrambled_exp = ifelse(any(category == 'unscramble'),
                                 RNA_exp_ave[category == 'unscramble'],
                                 NA),
           relative_exp = RNA_exp_ave / unscrambled_exp)
data <- data %>% 
    mutate(active = ifelse(RNA_exp_ave >= threshold, 'active', 'inactive'))
data %>% 
    ggplot(aes(scramble_start, relative_exp)) + geom_point(aes(color = active)) +
    scale_color_manual(values = c('red', 'black')) +
    scale_y_log10() +
    labs(x = 'scramble start', y= 'relative expression', color = '')

data %>% 
    filter(tss_name == 'TSS_2716_regulondb') %>% 
    ggplot(aes(scramble_start, relative_exp)) + geom_point(aes(color = active)) +
    scale_color_manual(values = c('red', 'black')) +
    scale_y_log10() + geom_hline(yintercept = 1, linetype = 'dashed') +
    labs(x = 'scramble start', y= 'relative expression', color = '')

data %>%
    mutate(active_relative = ifelse(relative_exp >= 1, 'active', 'inactive')) %>% 
    group_by(active_relative) %>% 
    tally()
# A tibble: 3 x 2
  active_relative     n
  <chr>           <int>
1 active          20304
2 inactive        27277
3 NA               5917

Only 68% of the library was mapped, so it seems many sequences are missing their unscrambled counterpart. After the next mapping run, we should get most of the library mapped. It’s probably best to classify each sequence as inactive/active relative to their unscrambled sequence. Anything with less expression than unscrambled will be “inactive” and anything higher as “active”.

corr <- cor(data$RNA_exp_1, data$RNA_exp_2)
ggplot(data, aes(RNA_exp_1, RNA_exp_2)) + geom_point() + 
    scale_x_log10() + scale_y_log10() + annotation_logticks(sides = 'bl') +
    labs(x = 'biological replicate 1', y = 'biological replicate 2') +
    annotate('text', x = 10, y = 0.1, label = paste0('r = ', signif(corr, 3)), size = 6)

Which k-mers are enriched in the active vs. inactive sequences? If the scrambled sequence has increased expression relative to unscrambled, we assume it is disrupting a repressive element. If the scrambled sequence has decreased expression relative to unscrambled, we assume it is disrupting an activating element.

bases <- c('A', 'T', 'G', 'C')
possible_kmers <- gtools::permutations(n = length(bases),
                                       v = bases, 
                                       r = k,
                                       repeats.allowed = T)
possible_kmers <- apply(possible_kmers, 1, paste, collapse='')
total_kmers_increased <- (150 - k + 1) * length(increased_set)
total_kmers_decreased <- (150 - k + 1) * length(decreased_set)
kmer_fisher <- function(kmer, df1, df2, df1_total, df2_total) {
    df1_count <- df1[kmer]
    df2_count <- df2[kmer]
    mat <-matrix(c(df1_count, df2_count,
                   df1_total - df1_count, 
                   df2_total - df2_count), nrow = 2)
    test <- fisher.test(mat)
    return(test)
}
tests <- mapply(kmer_fisher,
                kmer = possible_kmers,
                MoreArgs = list(
                    df1 = increased_kmer_freq,
                    df2 = decreased_kmer_freq,
                    df1_total = total_kmers_increased,
                    df2_total = total_kmers_decreased))
tests <- as.data.frame(t(tests))
tests$kmer <- rownames(tests)
tests <- tests %>% 
    mutate(p.value = as.numeric(p.value),
           estimate = as.numeric(estimate),
           p.value.adjusted = p.adjust(tests$p.value, method = 'fdr'))
signif_kmers_fdr <- tests %>% 
    filter(p.value.adjusted <= 0.05) %>% 
    arrange(p.value.adjusted) %>% 
    select(kmer, p.value, p.value.adjusted, estimate)
signif_kmers_fdr <- signif_kmers_fdr %>% 
    mutate(kmer_rc =
               as.character(Biostrings::reverseComplement(
                   DNAStringSet(signif_kmers_fdr$kmer)))) %>% 
    select(kmer, kmer_rc, p.value:estimate)
signif_kmers_fdr %>% 
    filter(estimate < 1) %>% nrow()
[1] 543
signif_kmers_fdr %>% 
    filter(estimate > 1) %>% nrow
[1] 491

Do these k-mer match any TF PWMs for E. coli?

# http://regulondb.ccg.unam.mx/menu/download/datasets/files/BindingSiteSet.txt
tf_sites <- read.table('../../ref/regulondb_tfbs.txt', comment.char = '#',
                       header = F, sep = '\t',
                       col.names = c('tf_id', 'tf_name', 'tfbs_id', 'tfbs_left',
                                     'tfbs_right', 'strand', 'tf_gene_id', 'tx_unit',
                                     'expression_effect', 'promoter_name',
                                     'center_pos_relative_tss', 'tfbs_sequence',
                                     'evidence', 'evidence_confidence'))
# extract TFBS from sequence, in upper case
# grab upper case part of site corresponding to binding site
extract_upper <- function(string, toString) {
    replace_lower <- strsplit(string, "[[:lower:]]*")[[1]]
    only_upper <- replace_lower[replace_lower != ""]
    if(toString == T) {
        return(paste(only_upper, collapse = ''))
    }
    else{
        return(only_upper)
    }
}
tf_sites$tfbs <- unlist(lapply(tf_sites$tfbs_sequence, extract_upper, toString = T))
signif_kmers_fdr <- signif_kmers_fdr %>% 
    group_by(kmer) %>% 
    mutate(tf_match_most_common = ifelse(any(grep(kmer, tf_sites$tfbs)),
                                         names(which.max(table(tf_sites$tf_name[grep(kmer,
                                                                                     tf_sites$tfbs)]))),
                                         NA),
           num_tf_match_most_common = ifelse(any(grep(kmer, tf_sites$tfbs)),
                                             max(table(tf_sites$tf_name[grep(kmer, tf_sites$tfbs)])),
                                             NA)) %>% 
    ungroup()
signif_kmers_fdr <- signif_kmers_fdr %>% 
    mutate(kmer_type = ifelse(estimate > 1, 'enriched', 'depleted'))
tf_counts <- signif_kmers_fdr %>% 
    group_by(kmer_type, tf_match_most_common) %>% 
    tally() %>% 
    arrange(desc(n))
tf_counts %>% 
    filter(n >= 10, !is.na(tf_match_most_common)) %>% 
    ggplot(aes(reorder(tf_match_most_common, n), n)) + 
    geom_bar(aes(fill = kmer_type), stat = 'identity', position = 'dodge') +
    scale_fill_manual(values = c('darkred', 'darkgreen')) +
    theme(axis.text.x = element_text(angle = 45, hjust = 1, size = 10)) +
    labs(x = 'TF', y = 'number of matching k-mers', fill = '')

NA

Most common TF is CRP, cAMP-activated global transcriptional regulator, which makes sense. Directly regulates transcription of ~300 genes in about 200 operons, indirectly regulates expression of about half the genome.

Next most common is Fis, DNA-binding protein Fis. Activates ribosomal RNA transcription, as well as other genes. Plays direct role in upstream activation of rRNA promoters.

Lrp, leucine-responsive regulatory protein. Mediates global response to leucine.

NarL, nitrate/nitrite response regulator protein, activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.

Instead of doing an exact match between the k-mer and the TFBS, let’s create an HMM for each TF and use that to score each k-mer.

create_phmm <- function(df, tf, n_iter = 10, verbose = F) {
    seq_list <- strsplit(toupper(filter(df, tf_name == tf)$tfbs), split = '')
    # for some reason, maybe the way the sequences are randomly aligned, the same
    # exact command will fail multiple times and then suceed. So, just keep trying
    # until it works
    phmm <- NULL
    attempt <- 0
    while(is.null(phmm) && attempt < n_iter) {
        attempt <- attempt + 1
        try (
            phmm <- derivePHMM(seq_list, maxsize = max(unlist(lapply(seq_list, length))), quiet = !verbose),
            silent = T
        )
    }
    if(attempt > 1) {
        print(paste("Number of attempts for", tf, ":", attempt))
    }
    if(is.null(phmm)) {
        return(NA)
    }
    else{
        return(phmm)
    }
}
tf_sites_with_sequence <- filter(tf_sites, tfbs != '')
tf_list <- as.list(unique(tf_sites_with_sequence$tf_name))
tf_phmms <- lapply(tf_list, create_phmm, df = tf_sites_with_sequence)
[1] "Number of attempts for AcrR : 10"
[1] "Number of attempts for CpxR : 10"
[1] "Number of attempts for Cra : 10"
[1] "Number of attempts for CytR : 10"
[1] "Number of attempts for Fis : 10"
[1] "Number of attempts for FlhDC : 5"
[1] "Number of attempts for FliZ : 10"
[1] "Number of attempts for Fur : 10"
[1] "Number of attempts for H-NS : 10"
[1] "Number of attempts for IHF : 10"
[1] "Number of attempts for IscR : 10"
[1] "Number of attempts for LexA : 10"
[1] "Number of attempts for Lrp : 10"
[1] "Number of attempts for NsrR : 10"
[1] "Number of attempts for PhoB : 10"
[1] "Number of attempts for PhoP : 4"
[1] "Number of attempts for YdeO : 10"
missing_phmms <- lapply(missing_tfs, create_phmm, df = tf_sites_with_sequence, n_iter = 20)
[1] "Number of attempts for AcrR : 20"
[1] "Number of attempts for CpxR : 20"
[1] "Number of attempts for Cra : 20"
[1] "Number of attempts for CytR : 8"
[1] "Number of attempts for Fis : 20"
[1] "Number of attempts for FliZ : 20"
[1] "Number of attempts for Fur : 20"
[1] "Number of attempts for H-NS : 20"
[1] "Number of attempts for IHF : 20"
[1] "Number of attempts for IscR : 20"
[1] "Number of attempts for LexA : 20"
[1] "Number of attempts for NsrR : 20"
[1] "Number of attempts for PhoB : 20"
[1] "Number of attempts for YdeO : 20"

Why is this happening? Let’s take Fis as an example.

fis_sites <- filter(tf_sites_with_sequence, tf_name == 'Fis')$tfbs
fis_seq_list <- strsplit(toupper(fis_sites), split = '')
derivePHMM(fis_seq_list)
Deriving profile HMM
Refining model
Iteration 1: alignment with 269 rows & 52 columns, PHMM with 20 modules
Error in tmp == hashis : non-conformable arrays

The initial alignment attempt has 52 columns, and maybe the multiple sequence alignment is just too unstable. Is there varying binding site lengths?

fis_site_lengths <- unlist(lapply(fis_seq_list, length))
table(fis_site_lengths)
fis_site_lengths
 15  19  20 
243  25   1 

Let’s only keep sites that are the predominant 15bp and see if this helps.

fis_seq_list_trimmed <- fis_seq_list[fis_site_lengths == 15]
derivePHMM(fis_seq_list_trimmed)
Deriving profile HMM
Refining model
Iteration 1: alignment with 243 rows & 15 columns, PHMM with 15 modules
Sequential alignments were identical after 1 iterations
Done
Profile hidden Markov model (object class: 'PHMM')
with 15 internal modules emitting 4 unique residues
(A, C, G, T).

If you trim the binding sites to only include 15bp, it works perfectly fine.

Hmm at least for the TFs that we couldn’t generate PHMMs, they all have at least two different binding site lengths. How true is this for all TFs?

Let’s see if there’s a way to tweak the alignment parameters before we just start eliminating sites.

derivePHMM(fis_seq_list, progressive = T, seeds = which(fis_site_lengths == 15)[1:25], maxsize=15)
Calculating sequence weights using maximum entropy method
Progressively aligning sequences
Deriving profile HMM
Refining model
Iteration 1: alignment with 269 rows & 48 columns, PHMM with 15 modules
Error in tmp == hashis : non-conformable arrays

Actually, let’s just use the position specific scoring matrices from RegulonDBs, then convert to PWMs.

python parse_regulondb_pssm.py ../../ref/regulondb_tf_pssm.txt regulondb_tf_pssm_parsed.txt
pwm_list <- PFMtoPWM(pfm_list, ids = as.character(tf_names))
Error in PWMUnscaled(motifs[[i]], id = id[i], name = name[i], ...) : 
  unused argument (ids = as.character(tf_names))

This actually won’t work because PWMs require the k-mer is at least as long as the PWM. Since we’re using 6-kmers and most PWMs are longer, this is a problem. Back to using PHMMs!

Let’s look at what k-mers are associated with relative expression, using simple linear regression. We only care about the significant ones.

kmer_counts <- kcount(x = strsplit(data$variant, split = ''), k = 6, residues = 'DNA')
kmer_counts_df <- data.frame(kmer_counts)
kmer_counts_df$expression <- data$relative_exp

Let’s first try individual linear regression for each k-mer and see how many are significant.

individ_kmer_reg <- function(kmer, kmer_counts_df) {
    counts <- select(kmer_counts_df, kmer, expression)
    model <- lm(log(expression) ~ ., counts)
    summary <- summary(model)
    # if k-mer count is too low, lm will return NA for coefficient
    if(nrow(summary$coefficients) == 2) {
        # get coefficient
        coeff <- summary$coefficients[2, 1]
        # get p-value of coefficient
        pval <- summary$coefficients[2, 4]
        return(list(c(coeff, pval)))
    }
    else {
        return(list(c(NA, NA)))
    }
}
# all_kmers <- as.list(colnames(kmer_counts))
# kmer_regression <- lapply(all_kmers, individ_kmer_reg, kmer_counts_df = kmer_counts_df)
# kmer_regression <- data.frame(matrix(unlist(kmer_regression), nrow = length(kmer_regression), byrow=T))
# colnames(kmer_regression) <- c('coeff', 'pval')
# kmer_regression$kmer <- unlist(all_kmers)
# save(kmer_regression, file = 'kmer_regression.rda')
load('kmer_regression.rda')
ggplot(kmer_regression, aes(log(pval))) + geom_histogram() +
    geom_vline(xintercept = log(0.05), col = 'red') +
    labs(x = 'log10(p-value) of linear regression coefficient',
         title = 'Individual linear regression between\n k-mer and expression')

signif_kmers_lm_fdr <- kmer_regression %>% 
    mutate(pval_fdr  = p.adjust(pval, method = 'fdr')) %>% 
    filter(pval_fdr <= 0.05)
print(nrow(signif_kmers_lm_fdr))
[1] 1252

K-mers to the left are significant.

# model_all_kmers <- lm(log(expression) ~ . , kmer_counts_df)
# saveRDS(model_all_kmers, file = 'model_all_kmers.rds', compress = T)
model_all_kmers <- readRDS('model_all_kmers.rds')
summary(model_all_kmers)

Call:
lm(formula = log(expression) ~ ., data = kmer_counts_df)

Residuals:
    Min      1Q  Median      3Q     Max 
-6.0489 -0.3032  0.0494  0.3603  3.9687 

Coefficients: (11 not defined because of singularities)
              Estimate Std. Error t value       Pr(>|t|)    
(Intercept) -4.4967005  1.4755591  -3.047       0.002309 ** 
AAAAAA       0.0346628  0.0158756   2.183       0.029011 *  
AAAAAC       0.1034533  0.1427408   0.725       0.468601    
AAAAAG       0.1104437  0.1343160   0.822       0.410929    
AAAAAT       0.0038834  0.1158833   0.034       0.973267    
AAAACA      -0.0678518  0.1641119  -0.413       0.679280    
AAAACC       0.0233996  0.1967573   0.119       0.905334    
AAAACG      -0.1696291  0.2156340  -0.787       0.431489    
AAAACT      -0.4432919  0.1844048  -2.404       0.016225 *  
AAAAGA      -0.2859106  0.1557424  -1.836       0.066395 .  
AAAAGC      -0.3636012  0.1743362  -2.086       0.037018 *  
AAAAGG      -0.1724975  0.2075501  -0.831       0.405915    
AAAAGT      -0.6326854  0.1466007  -4.316 0.000015944582 ***
AAAATA      -0.0244477  0.1383692  -0.177       0.859757    
AAAATC       0.0240097  0.1684269   0.143       0.886644    
AAAATG      -0.1048290  0.1390651  -0.754       0.450966    
AAAATT      -0.0024788  0.1344534  -0.018       0.985291    
AAACAA      -0.3024876  0.1832903  -1.650       0.098885 .  
AAACAC       0.3997055  0.1866562   2.141       0.032247 *  
AAACAG      -0.1141133  0.1738206  -0.657       0.511506    
AAACAT      -0.0277251  0.1830403  -0.151       0.879606    
AAACCA      -0.1495554  0.2185344  -0.684       0.493754    
AAACCC      -0.2620934  0.2795264  -0.938       0.348438    
AAACCG      -0.8421313  0.3181962  -2.647       0.008134 ** 
AAACCT       0.5405033  0.2049551   2.637       0.008363 ** 
AAACGA       0.2403261  0.2207904   1.088       0.276389    
AAACGC       0.0315989  0.2617952   0.121       0.903928    
AAACGG       0.0149145  0.2898193   0.051       0.958958    
AAACGT       0.1701203  0.2278278   0.747       0.455245    
AAACTA       0.0857504  0.2132647   0.402       0.687624    
AAACTC       0.2097300  0.2341909   0.896       0.370497    
AAACTG       0.1532242  0.2269878   0.675       0.499659    
AAACTT       0.2540304  0.1918823   1.324       0.185548    
AAAGAA       0.7307900  0.1842917   3.965 0.000073390968 ***
AAAGAC       0.2510245  0.2151438   1.167       0.243307    
AAAGAG       0.4474791  0.2070121   2.162       0.030654 *  
AAAGAT       0.0320280  0.1766654   0.181       0.856139    
AAAGCA       0.1507473  0.1803235   0.836       0.403169    
AAAGCC      -0.0915416  0.2013796  -0.455       0.649419    
AAAGCG       0.3935789  0.1900547   2.071       0.038377 *  
AAAGCT       0.8056594  0.3443603   2.340       0.019310 *  
AAAGGA      -0.0088592  0.2163742  -0.041       0.967341    
AAAGGC      -0.0976985  0.2993955  -0.326       0.744184    
AAAGGG       0.1872420  0.2587234   0.724       0.469245    
AAAGGT       0.2279107  0.2753221   0.828       0.407790    
AAAGTA      -0.1064875  0.2681563  -0.397       0.691288    
AAAGTC       0.0947602  0.3577904   0.265       0.791128    
AAAGTG       0.3497714  0.2219549   1.576       0.115064    
AAAGTT       0.5429140  0.2754658   1.971       0.048742 *  
AAATAA      -0.0495951  0.1488327  -0.333       0.738964    
AAATAC      -0.1149441  0.2338122  -0.492       0.622999    
AAATAG       0.0004822  0.1718163   0.003       0.997761    
AAATAT       0.0135287  0.1943632   0.070       0.944508    
AAATCA       0.1565364  0.1860283   0.841       0.400092    
AAATCC      -0.0232291  0.2099415  -0.111       0.911898    
AAATCG      -0.3032418  0.2235140  -1.357       0.174883    
AAATCT       0.1074538  0.2052164   0.524       0.600551    
AAATGA      -0.0542237  0.1601893  -0.338       0.734990    
AAATGC       0.4268177  0.1488635   2.867       0.004144 ** 
AAATGG       0.0727386  0.1600142   0.455       0.649417    
AAATGT       0.1869129  0.1683267   1.110       0.266825    
AAATTA       0.1321316  0.1528389   0.865       0.387309    
AAATTC       0.0865200  0.1935651   0.447       0.654891    
AAATTG      -0.1814945  0.1865643  -0.973       0.330645    
AAATTT       0.0223342  0.1457094   0.153       0.878179    
AACAAA       0.1920313  0.2017633   0.952       0.341221    
AACAAC      -0.1135769  0.2760572  -0.411       0.680763    
AACAAG       0.4150624  0.2554878   1.625       0.104258    
AACAAT       0.3141905  0.1915233   1.640       0.100912    
AACACA      -0.3005835  0.2437656  -1.233       0.217551    
AACACC      -0.2624175  0.2468887  -1.063       0.287834    
AACACG      -1.2119097  0.5506119  -2.201       0.027740 *  
AACACT      -0.4387450  0.2218416  -1.978       0.047964 *  
AACAGA      -0.2770701  0.2239493  -1.237       0.216019    
AACAGC      -0.3241661  0.1973328  -1.643       0.100444    
AACAGG      -0.3793827  0.1984238  -1.912       0.055885 .  
AACAGT      -0.4021401  0.2596114  -1.549       0.121387    
AACATA      -0.1738631  0.2073920  -0.838       0.401850    
AACATC       0.0811992  0.1814264   0.448       0.654473    
AACATG       0.3066691  0.2158485   1.421       0.155393    
AACATT       0.2244095  0.1818444   1.234       0.217182    
AACCAA       0.0170356  0.4520103   0.038       0.969936    
AACCAC      -0.2502666  0.2268100  -1.103       0.269851    
AACCAG      -0.0817182  0.3770534  -0.217       0.828421    
AACCAT      -0.1657344  0.2944852  -0.563       0.573578    
AACCCA      -0.0608393  0.2911965  -0.209       0.834505    
AACCCC      -0.1184167  0.3260446  -0.363       0.716463    
AACCCG       0.9098805  0.4111008   2.213       0.026884 *  
AACCCT       0.6487052  0.7643426   0.849       0.396047    
AACCGA       0.8936099  0.4042521   2.211       0.027074 *  
AACCGC       1.3117655  0.4219952   3.108       0.001882 ** 
AACCGG       1.1413546  0.7986643   1.429       0.152989    
AACCGT       0.4835298  0.3722034   1.299       0.193916    
AACCTA      -0.6859491  0.5353116  -1.281       0.200060    
AACCTC       0.2110583  0.7462665   0.283       0.777317    
AACCTG      -0.7078331  0.2392125  -2.959       0.003088 ** 
AACCTT       0.0535798  0.7348884   0.073       0.941879    
AACGAA      -0.4525533  0.1979641  -2.286       0.022257 *  
AACGAC      -0.3594477  0.7585636  -0.474       0.635607    
AACGAG      -0.2801743  0.2494505  -1.123       0.261373    
AACGAT      -0.1215099  0.1855301  -0.655       0.512514    
AACGCA      -0.2286689  0.3115990  -0.734       0.463040    
AACGCC      -0.0291978  0.2992390  -0.098       0.922271    
AACGCG       0.1849535  0.2290527   0.807       0.419399    
AACGCT      -0.0445065  0.2477571  -0.180       0.857438    
AACGGA       0.2861158  0.3298880   0.867       0.385776    
AACGGC       0.0870005  0.5747537   0.151       0.879684    
AACGGG      -0.7360682  0.3422389  -2.151       0.031502 *  
AACGGT      -0.3458252  0.3041472  -1.137       0.255531    
AACGTA      -0.4965596  0.2592710  -1.915       0.055472 .  
AACGTC       0.0341153  0.3948919   0.086       0.931156    
AACGTG      -0.2110725  0.4500381  -0.469       0.639065    
AACGTT      -0.2711435  0.1964192  -1.380       0.167461    
AACTAA       0.2112061  0.2391058   0.883       0.377070    
AACTAC       1.0088608  0.3150062   3.203       0.001363 ** 
AACTAG       1.3734763  0.5574378   2.464       0.013747 *  
AACTAT       0.5921140  0.2111937   2.804       0.005055 ** 
AACTCA       0.0301969  0.2751058   0.110       0.912596    
AACTCC      -0.4002988  0.3188215  -1.256       0.209283    
AACTCG       0.1566576  0.2963248   0.529       0.597038    
AACTCT       1.0830455  0.2770798   3.909 0.000092901833 ***
AACTGA       0.0948675  0.2543229   0.373       0.709135    
AACTGC       0.2690480  0.2341675   1.149       0.250581    
AACTGG       0.8542891  0.3490263   2.448       0.014384 *  
AACTGT       0.2101331  0.2523040   0.833       0.404930    
AACTTA       0.4309970  0.1933037   2.230       0.025777 *  
AACTTC      -0.1539476  0.2289870  -0.672       0.501397    
AACTTG       0.0800730  0.5250208   0.153       0.878782    
AACTTT       0.7029736  0.1810964   3.882       0.000104 ***
AAGAAA      -0.6761689  0.1779309  -3.800       0.000145 ***
AAGAAC      -0.7236264  0.2045952  -3.537       0.000405 ***
AAGAAG      -0.3197459  0.2001810  -1.597       0.110210    
AAGAAT      -0.6813880  0.2066171  -3.298       0.000975 ***
AAGACA      -0.6981306  0.5471585  -1.276       0.201990    
AAGACC      -1.4004383  0.3852624  -3.635       0.000278 ***
AAGACG      -0.1895385  0.2289114  -0.828       0.407675    
AAGACT       0.1414009  0.2519421   0.561       0.574634    
AAGAGA      -0.2321768  0.2599642  -0.893       0.371803    
AAGAGC      -0.2214761  0.2384291  -0.929       0.352948    
AAGAGG      -0.1581750  0.2504908  -0.631       0.527743    
AAGAGT      -0.3384405  0.2222687  -1.523       0.127850    
AAGATA      -0.0636478  0.1982384  -0.321       0.748161    
AAGATC       0.4533621  0.2086107   2.173       0.029767 *  
AAGATG       0.1878509  0.2236342   0.840       0.400918    
AAGATT       0.3012269  0.1960917   1.536       0.124508    
AAGCAA       0.0939013  0.1797835   0.522       0.601463    
AAGCAC       0.0537352  0.1985355   0.271       0.786655    
AAGCAG       0.4218254  0.2302250   1.832       0.066924 .  
AAGCAT       0.3714247  0.2229722   1.666       0.095763 .  
AAGCCA       0.4864016  0.1860518   2.614       0.008943 ** 
AAGCCC       0.3843087  0.2722818   1.411       0.158123    
AAGCCG       0.2187312  0.2341019   0.934       0.350133    
AAGCCT       0.0934850  0.2449765   0.382       0.702754    
AAGCGA      -0.3886433  0.1760524  -2.208       0.027281 *  
AAGCGC      -0.2316992  0.2269776  -1.021       0.307354    
AAGCGG      -0.0534090  0.2455940  -0.217       0.827844    
AAGCGT      -0.0622070  0.2285067  -0.272       0.785444    
AAGCTA      -0.5494474  0.3819475  -1.439       0.150288    
AAGCTC      -1.4675030  0.3774226  -3.888       0.000101 ***
AAGCTG      -0.1064719  0.6111731  -0.174       0.861702    
AAGCTT      -0.7959320  0.3464732  -2.297       0.021610 *  
AAGGAA       0.0999732  0.2048616   0.488       0.625550    
AAGGAC      -1.2837388  0.7501535  -1.711       0.087033 .  
AAGGAG       0.2429174  0.1880737   1.292       0.196500    
AAGGAT      -0.0331754  0.2234415  -0.148       0.881969    
AAGGCA      -0.0621059  0.2837675  -0.219       0.826759    
AAGGCC       0.6177923  0.3385671   1.825       0.068049 .  
AAGGCG       0.1623371  0.2935539   0.553       0.580262    
AAGGCT       0.3844371  0.3117596   1.233       0.217538    
AAGGGA       0.0805338  0.2771780   0.291       0.771398    
AAGGGC      -0.1490703  0.3440801  -0.433       0.664840    
AAGGGG       0.0181695  0.2649113   0.069       0.945319    
AAGGGT      -0.4096410  0.2311405  -1.772       0.076358 .  
AAGGTA      -0.1189957  0.2844228  -0.418       0.675674    
AAGGTC       0.0171191  0.3003201   0.057       0.954543    
AAGGTG      -0.4434591  0.3331896  -1.331       0.183212    
AAGGTT      -0.3034563  0.2430401  -1.249       0.211823    
AAGTAA       1.0599105  0.2877806   3.683       0.000231 ***
AAGTAC       0.0846495  0.3702650   0.229       0.819166    
AAGTAG       0.7045046  0.3481783   2.023       0.043038 *  
AAGTAT       0.6707056  0.2926125   2.292       0.021903 *  
AAGTCA       0.9830651  0.3933616   2.499       0.012453 *  
AAGTCC       0.3392590  0.3836665   0.884       0.376563    
AAGTCG       0.5987267  0.4343519   1.378       0.168075    
AAGTCT       0.2961262  0.4193031   0.706       0.480046    
AAGTGA      -0.5937189  0.2590594  -2.292       0.021920 *  
AAGTGC       0.4859465  0.2969536   1.636       0.101755    
AAGTGG       0.4163521  0.2674746   1.557       0.119572    
AAGTGT       0.1751103  0.2808230   0.624       0.532919    
AAGTTA      -0.0470287  0.2929976  -0.161       0.872481    
AAGTTC      -0.0640105  0.2868914  -0.223       0.823445    
AAGTTG       0.3392449  0.7703622   0.440       0.659671    
AAGTTT      -0.1734642  0.2824102  -0.614       0.539068    
AATAAA       0.3020764  0.1318247   2.292       0.021939 *  
AATAAC       0.1044976  0.1358761   0.769       0.441859    
AATAAG      -0.0286992  0.1522021  -0.189       0.850439    
AATAAT       0.2697484  0.1381288   1.953       0.050841 .  
AATACA       0.3997844  0.2482082   1.611       0.107256    
AATACC       0.6503354  0.3794411   1.714       0.086549 .  
AATACG       0.1875402  0.2609151   0.719       0.472281    
 [ reached getOption("max.print") -- omitted 3897 rows ]
---
Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1

Residual standard error: 0.696 on 43495 degrees of freedom
  (5917 observations deleted due to missingness)
Multiple R-squared:  0.267, Adjusted R-squared:  0.1982 
F-statistic: 3.879 on 4085 and 43495 DF,  p-value: < 0.00000000000000022

Let’s see how many significant k-mers from individual linear regression compared to those from Fisher test enrichments.

coeff <- summary(model_all_kmers)$coefficients
coeff <- coeff[-1,]
signif_kmers_multiple_lm <- unlist(dimnames(coeff)[1][coeff[,4] <= 0.05])
# how many significant in both?
signif_kmers_overlap <- signif_kmers_fdr %>% 
    left_join(data.frame(kmer = signif_kmers_multiple_lm, lm_coeff = coeff[,1], lm_pval = coeff[,4]), 
              by = 'kmer') %>% 
    filter(!is.na(lm_coeff))
print(nrow(signif_kmers_overlap) / nrow(signif_kmers_fdr))
[1] 0.9961315

Good, most of them. How do the direction of their effects compare?

Hmm they don’t always match up, I’ll go with the linear regression more than the Fisher because it doesn’t have any classification into “active” or “inactive” and is just based on the relative expression value.

Let’s take a quick look at the coefficients.

What are these k-mers? Do they hit TFs?

signif_kmers_lm_fdr <- signif_kmers_lm_fdr %>% 
    group_by(kmer) %>% 
    mutate(tf_match_most_common = ifelse(any(grep(kmer, tf_sites$tfbs_sequence)),
                                         names(which.max(
                                             table(
                                                 tf_sites$tf_name[
                                                     grep(kmer, tf_sites$tfbs_sequence)])
                                             )), 
                                         NA)
    )

What are the range of coefficients for each TF?

Negative coefficients implies k-mer count is inversely correlated with expression. Positive coefficeints implies k-mer count is positively correlated with expression. For example,

Let’s run multiple regression again but with only the significant k-mers.

kmer_counts_signif <- select_(kmer_counts_df, .dots = signif_kmers_lm_fdr$kmer)
kmer_counts_signif$expression <- kmer_counts_df$expression
model_signif_kmers <- lm(log(expression) ~ . , kmer_counts_signif)
summary(model_signif_kmers)

Call:
lm(formula = log(expression) ~ ., data = kmer_counts_signif)

Residuals:
    Min      1Q  Median      3Q     Max 
-6.3819 -0.2844  0.0768  0.3766  4.3248 

Coefficients:
               Estimate  Std. Error t value             Pr(>|t|)    
(Intercept) -0.30890352  0.03801217  -8.126 0.000000000000000453 ***
AAAAAA       0.00434197  0.00822279   0.528             0.597473    
AAAAAC      -0.00648140  0.01713670  -0.378             0.705271    
AAAAAG      -0.01823988  0.01685400  -1.082             0.279157    
AAAAAT       0.00055872  0.01387324   0.040             0.967876    
AAAACG      -0.05840539  0.02459502  -2.375             0.017568 *  
AAAAGC       0.02058264  0.01974592   1.042             0.297244    
AAAAGG       0.04480753  0.02013851   2.225             0.026088 *  
AAAAGT      -0.02483951  0.01801910  -1.379             0.168053    
AAAATT      -0.04825498  0.01403867  -3.437             0.000588 ***
AAACAG      -0.04943112  0.01927990  -2.564             0.010354 *  
AAACCA      -0.01669646  0.01992655  -0.838             0.402091    
AAACCT       0.03456437  0.02629653   1.314             0.188715    
AAACGA       0.04281810  0.03757260   1.140             0.254455    
AAACGC       0.06223080  0.02786662   2.233             0.025543 *  
AAACGT      -0.00122020  0.02976225  -0.041             0.967298    
AAACTG      -0.02401282  0.02372869  -1.012             0.311556    
AAAGCA       0.01479123  0.02209281   0.670             0.503177    
AAAGCG      -0.00820831  0.02246070  -0.365             0.714775    
AAAGGA       0.02891345  0.02280243   1.268             0.204805    
AAAGGC      -0.03630259  0.02463383  -1.474             0.140572    
AAAGTA      -0.00962764  0.02000412  -0.481             0.630318    
AAATAT       0.02504872  0.01654050   1.514             0.129935    
AAATCC       0.00513753  0.02003686   0.256             0.797640    
AAATGC      -0.08065266  0.01724900  -4.676 0.000002936527468966 ***
AAATTT      -0.00843376  0.01589396  -0.531             0.595680    
AACAAA       0.02406502  0.02229136   1.080             0.280340    
AACAAC      -0.01794779  0.02433063  -0.738             0.460723    
AACAAT       0.04620472  0.02473605   1.868             0.061781 .  
AACACC       0.04517806  0.02700382   1.673             0.094329 .  
AACACG      -0.03392832  0.03825992  -0.887             0.375199    
AACATA       0.03411380  0.02079680   1.640             0.100942    
AACATC       0.02521342  0.02015173   1.251             0.210875    
AACATG       0.02686663  0.02213418   1.214             0.224828    
AACATT       0.01117927  0.01802217   0.620             0.535059    
AACCAA      -0.02129134  0.02794335  -0.762             0.446096    
AACCGA      -0.12277487  0.03535238  -3.473             0.000515 ***
AACCTA      -0.00192959  0.03293139  -0.059             0.953276    
AACCTC       0.09657681  0.03573622   2.702             0.006885 ** 
AACCTT       0.01829238  0.02365405   0.773             0.439331    
AACGAA      -0.01133738  0.03810072  -0.298             0.766038    
AACGAC      -0.01758595  0.04583774  -0.384             0.701235    
AACGAT      -0.03884870  0.03905207  -0.995             0.319842    
AACGCG      -0.00121389  0.02777880  -0.044             0.965145    
AACGTG      -0.09291112  0.02761440  -3.365             0.000767 ***
AACGTT       0.04041376  0.02584499   1.564             0.117895    
AACTCA      -0.05497432  0.02591892  -2.121             0.033926 *  
AACTCG      -0.05188727  0.03840538  -1.351             0.176689    
AACTCT       0.07873203  0.02880000   2.734             0.006264 ** 
AACTGA      -0.00788876  0.02682936  -0.294             0.768733    
AACTGC       0.02298311  0.02925435   0.786             0.432088    
AACTTG      -0.03681373  0.02841400  -1.296             0.195113    
AAGAAC      -0.04839534  0.02945740  -1.643             0.100412    
AAGAAG      -0.04908516  0.02391094  -2.053             0.040094 *  
AAGACA       0.04160404  0.02914681   1.427             0.153472    
AAGAGC       0.05419296  0.02892047   1.874             0.060956 .  
AAGATA      -0.06345340  0.01995376  -3.180             0.001474 ** 
AAGATC       0.01243106  0.02883235   0.431             0.666361    
AAGCAA      -0.00503979  0.02096836  -0.240             0.810058    
AAGCAC       0.00830795  0.02896168   0.287             0.774221    
AAGCGG      -0.03243257  0.02771368  -1.170             0.241897    
AAGCTA      -0.05348907  0.02734676  -1.956             0.050476 .  
AAGGCC       0.03072505  0.03871857   0.794             0.427463    
AAGGCT       0.02572041  0.03407941   0.755             0.450421    
AAGGGC       0.01050877  0.03134959   0.335             0.737466    
AAGGGG       0.01863515  0.03114720   0.598             0.549647    
AAGGTT      -0.00865767  0.02370239  -0.365             0.714915    
AAGTTT      -0.00822470  0.02060736  -0.399             0.689811    
AATACA       0.06263944  0.02260041   2.772             0.005580 ** 
AATAGA       0.00613824  0.02350861   0.261             0.794012    
AATAGT      -0.00269683  0.02427407  -0.111             0.911538    
AATATA       0.01170722  0.02063295   0.567             0.570442    
AATATC      -0.04642274  0.01942804  -2.389             0.016877 *  
AATATG      -0.00405110  0.02141826  -0.189             0.849982    
AATCAC      -0.05200319  0.02247747  -2.314             0.020696 *  
AATCCT      -0.01738987  0.02406288  -0.723             0.469877    
AATCTA      -0.01112128  0.02896954  -0.384             0.701058    
AATGCG       0.01753381  0.02059933   0.851             0.394672    
AATGGC      -0.00855939  0.02099067  -0.408             0.683444    
AATGGT       0.00444812  0.02504891   0.178             0.859056    
AATGTA      -0.01322579  0.02108719  -0.627             0.530534    
AATGTG       0.03257457  0.01974388   1.650             0.098979 .  
AATTAT       0.05760757  0.01948958   2.956             0.003120 ** 
AATTCC       0.00199822  0.02249287   0.089             0.929211    
AATTTA      -0.02549466  0.01509163  -1.689             0.091164 .  
AATTTC      -0.03394645  0.01915121  -1.773             0.076310 .  
AATTTG       0.05245184  0.02080484   2.521             0.011701 *  
AATTTT      -0.01220794  0.01465427  -0.833             0.404813    
ACAAAA      -0.00481080  0.02099861  -0.229             0.818792    
ACAAAT      -0.03089400  0.02214993  -1.395             0.163093    
ACAACG      -0.05579025  0.02709751  -2.059             0.039512 *  
ACAACT      -0.01977051  0.03101628  -0.637             0.523852    
ACAATA      -0.04237639  0.02549661  -1.662             0.096511 .  
ACAATC      -0.05506017  0.02810526  -1.959             0.050111 .  
ACAATT      -0.00763583  0.02522743  -0.303             0.762135    
ACACAT      -0.05413574  0.02606310  -2.077             0.037798 *  
ACACCG       0.02993431  0.03245021   0.922             0.356289    
ACACGA      -0.00061195  0.04356299  -0.014             0.988792    
ACACGC       0.07264561  0.04209101   1.726             0.084369 .  
ACACGG       0.02781476  0.04475326   0.622             0.534265    
ACAGAC      -0.06537753  0.03112026  -2.101             0.035664 *  
ACAGCA       0.02093989  0.03403850   0.615             0.538437    
ACAGCT       0.07806835  0.03229509   2.417             0.015638 *  
ACATAA      -0.02485295  0.02146362  -1.158             0.246907    
ACATAC      -0.10612408  0.02851754  -3.721             0.000198 ***
ACATAG       0.07248259  0.03297854   2.198             0.027963 *  
ACATCT       0.06278010  0.02292731   2.738             0.006180 ** 
ACATGG      -0.04481365  0.03063662  -1.463             0.143543    
ACATTG       0.07618923  0.02387658   3.191             0.001419 ** 
ACCAAA      -0.05406428  0.02520540  -2.145             0.031962 *  
ACCAAG      -0.07523934  0.04202514  -1.790             0.073406 .  
ACCACG      -0.08155554  0.03775269  -2.160             0.030758 *  
ACCATA      -0.01283445  0.02772975  -0.463             0.643481    
ACCATC       0.03536823  0.02802673   1.262             0.206974    
ACCCCA      -0.07591990  0.03328358  -2.281             0.022553 *  
ACCCCG      -0.01006831  0.03944345  -0.255             0.798524    
ACCGAA       0.09070944  0.03549101   2.556             0.010596 *  
ACCGAC       0.05720835  0.03422823   1.671             0.094654 .  
ACCGGC      -0.02336629  0.03874509  -0.603             0.546460    
ACCGGT      -0.05577167  0.04270943  -1.306             0.191614    
ACCGTA      -0.08198917  0.03326271  -2.465             0.013709 *  
ACCTAC       0.04950669  0.04404683   1.124             0.261038    
ACCTCT      -0.10620800  0.03338804  -3.181             0.001469 ** 
ACCTGT       0.01400613  0.02526661   0.554             0.579353    
ACCTTC       0.01274901  0.03067254   0.416             0.677669    
ACGAAC      -0.06744141  0.03651479  -1.847             0.064759 .  
ACGAAG       0.03062168  0.03409718   0.898             0.369153    
ACGAAT       0.00740583  0.02746450   0.270             0.787430    
ACGACA       0.01031014  0.04044516   0.255             0.798789    
ACGACG      -0.10603092  0.04033904  -2.628             0.008579 ** 
ACGATC       0.08554000  0.03567667   2.398             0.016505 *  
ACGATG       0.03137694  0.03339516   0.940             0.347445    
ACGATT      -0.01635874  0.02763742  -0.592             0.553917    
ACGCCA      -0.04963752  0.02481847  -2.000             0.045504 *  
ACGCTA      -0.08941312  0.03251800  -2.750             0.005968 ** 
ACGCTG      -0.05568801  0.02747102  -2.027             0.042652 *  
ACGCTT       0.03900611  0.02705346   1.442             0.149361    
ACGGAC      -0.06699623  0.04227978  -1.585             0.113066    
ACGGAT       0.01423083  0.03288796   0.433             0.665230    
ACGGCT       0.04952514  0.03102412   1.596             0.110419    
ACGGGG      -0.04838074  0.03819598  -1.267             0.205289    
ACGTCA       0.05075582  0.02729165   1.860             0.062926 .  
ACGTCG       0.06486230  0.03972145   1.633             0.102491    
ACGTTA      -0.08210589  0.02602692  -3.155             0.001608 ** 
ACGTTC       0.04557785  0.03730121   1.222             0.221757    
ACGTTT      -0.04551824  0.02416693  -1.883             0.059640 .  
ACTAAG       0.08649737  0.03817665   2.266             0.023473 *  
ACTACA      -0.06225711  0.03095016  -2.012             0.044276 *  
ACTACC       0.05860704  0.03598821   1.629             0.103424    
ACTATC       0.01330288  0.03581568   0.371             0.710322    
ACTCGA      -0.00908249  0.05129361  -0.177             0.859455    
ACTCTG      -0.00009765  0.03276199  -0.003             0.997622    
ACTGAG       0.13395064  0.05186372   2.583             0.009805 ** 
ACTGCG      -0.08460424  0.03165682  -2.673             0.007530 ** 
ACTGCT      -0.07188756  0.03205382  -2.243             0.024920 *  
ACTGGA      -0.03236605  0.02565908  -1.261             0.207176    
ACTTAT      -0.00716207  0.02011854  -0.356             0.721847    
ACTTCG       0.04137434  0.03069999   1.348             0.177762    
ACTTTA       0.02251267  0.01777773   1.266             0.205397    
ACTTTG      -0.06499289  0.02253628  -2.884             0.003929 ** 
AGAAAA      -0.01519460  0.01696324  -0.896             0.370398    
AGAACA      -0.03934841  0.02752780  -1.429             0.152894    
AGAATA      -0.04364856  0.02021496  -2.159             0.030838 *  
AGAATC       0.02574459  0.02542278   1.013             0.311229    
AGACAA      -0.05286864  0.02969818  -1.780             0.075050 .  
AGACAG      -0.03755090  0.03275858  -1.146             0.251680    
AGACGA      -0.08303362  0.03298838  -2.517             0.011837 *  
AGACTT       0.02300946  0.02586056   0.890             0.373604    
AGAGTG       0.06188758  0.02508691   2.467             0.013631 *  
AGATAC       0.00360332  0.03449160   0.104             0.916797    
AGATCG       0.08286773  0.03057748   2.710             0.006729 ** 
AGATGA      -0.10786633  0.08080641  -1.335             0.181924    
AGATTA       0.00701791  0.02066421   0.340             0.734147    
AGATTG       0.04448671  0.02138419   2.080             0.037498 *  
AGCAAG      -0.05697774  0.02637486  -2.160             0.030754 *  
AGCACA      -0.05033715  0.03209398  -1.568             0.116788    
AGCACT      -0.03847891  0.03254978  -1.182             0.237150    
AGCAGA      -0.04329866  0.02820399  -1.535             0.124742    
AGCAGG       0.06610018  0.02693366   2.454             0.014124 *  
AGCAGT      -0.07334428  0.02886027  -2.541             0.011045 *  
AGCCAT      -0.06449470  0.02498634  -2.581             0.009849 ** 
AGCCGG      -0.04520250  0.03592772  -1.258             0.208344    
AGCGAA      -0.03712854  0.02393078  -1.551             0.120789    
AGCGAG      -0.09351445  0.03413552  -2.740             0.006156 ** 
AGCGGC      -0.04049497  0.03447445  -1.175             0.240146    
AGCGTT      -0.02598932  0.02718647  -0.956             0.339095    
AGCTGT       0.08566730  0.03115481   2.750             0.005967 ** 
AGCTTG       0.00520686  0.03463014   0.150             0.880484    
AGGAAA      -0.00869007  0.02139139  -0.406             0.684567    
AGGACC      -0.01243861  0.04955451  -0.251             0.801809    
AGGAGC       0.03082679  0.04143346   0.744             0.456876    
AGGAGG      -0.03922422  0.04447811  -0.882             0.377848    
AGGAGT       0.00207631  0.03011099   0.069             0.945026    
AGGATG       0.08959672  0.02969274   3.017             0.002550 ** 
AGGATT       0.02931155  0.02612289   1.122             0.261841    
AGGCAA       0.00842560  0.02732757   0.308             0.757841    
AGGCAG       0.05865355  0.03266642   1.796             0.072576 .  
AGGCCA      -0.03264948  0.03914308  -0.834             0.404226    
AGGCCG      -0.10639063  0.03599921  -2.955             0.003125 ** 
AGGCCT      -0.07423212  0.04013318  -1.850             0.064371 .  
 [ reached getOption("max.print") -- omitted 1053 rows ]
---
Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1

Residual standard error: 0.7249 on 46328 degrees of freedom
  (5917 observations deleted due to missingness)
Multiple R-squared:  0.1529,    Adjusted R-squared:   0.13 
F-statistic: 6.679 on 1252 and 46328 DF,  p-value: < 0.00000000000000022

Hmm, the model does worse, which isn’t too surprising since we remove a lot of variables.

signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    summarise(n = n()) %>% 
    arrange(desc(n))

Let’s take k-mers that match to top 5 TFs and see what this small model looks like.

top_tfs <- signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    summarise(n = n()) %>% 
    arrange(desc(n)) %>% 
    top_n(5) %>% .$tf_match_most_common
Selecting by n
kmer_tf_subset <- select_(kmer_counts_df, .dots = 
                              filter(signif_kmers_lm_fdr, tf_match_most_common %in% top_tfs) %>% .$kmer)
kmer_tf_subset$expression <- kmer_counts_df$expression
model_tf_subset <- lm(expression ~ . , kmer_tf_subset)
summary(model_tf_subset)

Call:
lm(formula = expression ~ ., data = kmer_tf_subset)

Residuals:
   Min     1Q Median     3Q    Max 
-2.038 -0.451 -0.144  0.155 56.725 

Coefficients:
              Estimate Std. Error t value             Pr(>|t|)    
(Intercept)  0.9749748  0.0401750  24.268 < 0.0000000000000002 ***
AAAAAA      -0.0061672  0.0143182  -0.431             0.666673    
AAAAAC      -0.0036803  0.0283064  -0.130             0.896553    
AAAAAG      -0.0301875  0.0268088  -1.126             0.260159    
AAAAAT       0.0070495  0.0227474   0.310             0.756637    
AAAAGT      -0.0392561  0.0305887  -1.283             0.199375    
AAACAG      -0.0271519  0.0320349  -0.848             0.396679    
AAACGT      -0.0683979  0.0380641  -1.797             0.072356 .  
AAACTG      -0.0590590  0.0358051  -1.649             0.099061 .  
AAAGCG      -0.0258121  0.0329163  -0.784             0.432943    
AAAGGA       0.0316571  0.0377590   0.838             0.401811    
AAAGTA       0.0042980  0.0339669   0.127             0.899309    
AAATAT       0.0324755  0.0245361   1.324             0.185650    
AAATCC      -0.0479755  0.0338925  -1.416             0.156923    
AAATGC      -0.0203362  0.0284134  -0.716             0.474164    
AAATTT       0.0568125  0.0239034   2.377             0.017470 *  
AACAAA      -0.0347280  0.0325130  -1.068             0.285469    
AACACC       0.0329913  0.0463548   0.712             0.476645    
AACACG      -0.0882816  0.0552528  -1.598             0.110099    
AACATC       0.0805475  0.0337698   2.385             0.017074 *  
AACATG      -0.0014276  0.0375766  -0.038             0.969694    
AACATT      -0.0065428  0.0301882  -0.217             0.828416    
AACCAA      -0.0369513  0.0434694  -0.850             0.395300    
AACCTC       0.1151940  0.0590894   1.949             0.051243 .  
AACGAA      -0.0177052  0.0412088  -0.430             0.667455    
AACGTG      -0.0487307  0.0462709  -1.053             0.292272    
AACTCA      -0.0326836  0.0434917  -0.751             0.452362    
AACTGA      -0.0369097  0.0437235  -0.844             0.398583    
AAGATC       0.0140474  0.0490131   0.287             0.774416    
AAGGCC      -0.0766659  0.0575683  -1.332             0.182953    
AATAGA      -0.0128498  0.0391495  -0.328             0.742743    
AATATG       0.0060841  0.0337136   0.180             0.856790    
AATCAC       0.0232921  0.0377294   0.617             0.537010    
AATCCT       0.0834822  0.0398608   2.094             0.036235 *  
AATGTG       0.0587228  0.0327984   1.790             0.073394 .  
AATTTC      -0.0160975  0.0284415  -0.566             0.571405    
AATTTG       0.0044112  0.0330391   0.134             0.893787    
AATTTT       0.0124287  0.0219368   0.567             0.571011    
ACAAAA      -0.0266217  0.0351010  -0.758             0.448198    
ACAAAT      -0.0175117  0.0368641  -0.475             0.634765    
ACAACT      -0.0393199  0.0433222  -0.908             0.364087    
ACAATA      -0.0060215  0.0305708  -0.197             0.843853    
ACAATT       0.0206947  0.0301875   0.686             0.493007    
ACACAT      -0.0615743  0.0455523  -1.352             0.176468    
ACACCG       0.1413947  0.0494335   2.860             0.004234 ** 
ACACGC       0.0091023  0.0669598   0.136             0.891872    
ACAGAC      -0.0762503  0.0489867  -1.557             0.119584    
ACAGCA      -0.0630842  0.0403412  -1.564             0.117879    
ACAGCT       0.1779348  0.0564735   3.151             0.001629 ** 
ACATAA      -0.0615471  0.0311053  -1.979             0.047859 *  
ACATAG       0.0745688  0.0546597   1.364             0.172499    
ACATCT       0.1008930  0.0383880   2.628             0.008586 ** 
ACATGG      -0.0726741  0.0508539  -1.429             0.152989    
ACATTG       0.0781677  0.0388967   2.010             0.044477 *  
ACCAAA      -0.0290820  0.0404260  -0.719             0.471904    
ACCAAG      -0.0094985  0.0709589  -0.134             0.893514    
ACCATA       0.0529996  0.0416210   1.273             0.202888    
ACCATC      -0.0117153  0.0451365  -0.260             0.795209    
ACCCCA       0.0739384  0.0519730   1.423             0.154850    
ACCCCG      -0.0277527  0.0626101  -0.443             0.657578    
ACCGAA      -0.0525009  0.0593721  -0.884             0.376555    
ACCGGC      -0.0773834  0.0606885  -1.275             0.202283    
ACCGTA      -0.1622923  0.0563186  -2.882             0.003957 ** 
ACCTCT      -0.0763415  0.0564817  -1.352             0.176505    
ACGAAT       0.0380689  0.0437921   0.869             0.384683    
ACGACA       0.0579181  0.0647266   0.895             0.370893    
ACGACG      -0.0220005  0.0669070  -0.329             0.742292    
ACGATC      -0.0008746  0.0569558  -0.015             0.987748    
ACGCTA      -0.0262610  0.0485016  -0.541             0.588203    
ACGCTG       0.0496074  0.0445837   1.113             0.265852    
ACGCTT       0.0718369  0.0441195   1.628             0.103482    
ACGGAC      -0.0360435  0.0707392  -0.510             0.610385    
ACGGAT      -0.0158453  0.0519194  -0.305             0.760223    
ACGGGG      -0.0223775  0.0632190  -0.354             0.723364    
ACGTCA       0.0108328  0.0452873   0.239             0.810950    
ACGTTA      -0.0364488  0.0390734  -0.933             0.350913    
ACTACC       0.0161833  0.0563816   0.287             0.774090    
ACTCTG       0.0481371  0.0496147   0.970             0.331943    
ACTGAG       0.2001856  0.0829175   2.414             0.015770 *  
ACTGCG      -0.0632573  0.0476632  -1.327             0.184458    
ACTTAT      -0.0011373  0.0338581  -0.034             0.973205    
AGAAAA       0.0301105  0.0291131   1.034             0.301020    
AGAATA       0.0254565  0.0343763   0.741             0.458985    
AGACAA      -0.0338396  0.0408985  -0.827             0.408012    
AGAGTG       0.0582759  0.0435824   1.337             0.181183    
AGATAC       0.0128828  0.0547378   0.235             0.813934    
AGATCG       0.0549217  0.0527391   1.041             0.297702    
AGATGA       0.0304147  0.0447670   0.679             0.496887    
AGATTA       0.0356649  0.0321913   1.108             0.267908    
AGATTG       0.0705940  0.0341670   2.066             0.038820 *  
AGCACA      -0.0693810  0.0479502  -1.447             0.147920    
AGCACT      -0.0722368  0.0496310  -1.455             0.145543    
AGCAGG       0.0818555  0.0458182   1.787             0.074020 .  
AGCAGT      -0.0301990  0.0483760  -0.624             0.532462    
AGCGAA      -0.0397309  0.0385753  -1.030             0.303035    
AGCGAG      -0.1067247  0.0572575  -1.864             0.062336 .  
AGCGTT      -0.0200157  0.0417412  -0.480             0.631572    
AGCTGT       0.1051561  0.0529400   1.986             0.047003 *  
AGGAAA       0.0302541  0.0363904   0.831             0.405766    
AGGAGT      -0.0304315  0.0517310  -0.588             0.556358    
AGGCAA       0.0029479  0.0454739   0.065             0.948313    
AGGCAG       0.0837007  0.0566365   1.478             0.139453    
AGGCCA       0.0649186  0.0626718   1.036             0.300278    
AGGCCT      -0.0860851  0.0693560  -1.241             0.214536    
AGGCGA      -0.0898085  0.0516753  -1.738             0.082229 .  
AGGGGT       0.0128960  0.0549732   0.235             0.814530    
AGGGTC       0.0430534  0.0959635   0.449             0.653691    
AGGTAT       0.0248674  0.0424756   0.585             0.558248    
AGGTGC       0.0884942  0.0438915   2.016             0.043784 *  
AGTATA       0.0989939  0.0416293   2.378             0.017411 *  
AGTCAC       0.0233561  0.0558442   0.418             0.675776    
AGTCAG      -0.0022718  0.0437565  -0.052             0.958593    
AGTCGG      -0.1518141  0.0664705  -2.284             0.022380 *  
AGTGAC      -0.0427663  0.0531882  -0.804             0.421369    
AGTGCC      -0.0094010  0.0534021  -0.176             0.860262    
AGTGGG       0.1452407  0.0790235   1.838             0.066077 .  
AGTTAG      -0.1136120  0.0503138  -2.258             0.023946 *  
AGTTCA      -0.0007266  0.0395515  -0.018             0.985343    
AGTTGG      -0.0507000  0.0537018  -0.944             0.345123    
ATAAAC      -0.0376604  0.0297837  -1.264             0.206070    
ATACGC      -0.0484596  0.0470040  -1.031             0.302562    
ATACTA      -0.0078307  0.0494801  -0.158             0.874252    
ATACTG      -0.0040397  0.0357565  -0.113             0.910048    
ATAGAG       0.0248935  0.0527540   0.472             0.637015    
ATAGAT      -0.0142304  0.0394523  -0.361             0.718327    
ATAGGA       0.0039475  0.0734717   0.054             0.957152    
ATAGTG       0.0364849  0.0371702   0.982             0.326320    
ATATGA      -0.0730751  0.0396950  -1.841             0.065640 .  
ATCAAA      -0.0107741  0.0292909  -0.368             0.713000    
ATCACA       0.0429447  0.0408734   1.051             0.293413    
ATCAGG      -0.0625007  0.0347430  -1.799             0.072034 .  
ATCATA      -0.0027445  0.0367608  -0.075             0.940488    
ATCCCA       0.0646488  0.0486339   1.329             0.183757    
ATCCCC      -0.1135146  0.0485927  -2.336             0.019493 *  
ATCCGG      -0.0249805  0.0487685  -0.512             0.608495    
ATCGTA       0.0195135  0.0473673   0.412             0.680369    
ATCTAT       0.0124991  0.0342187   0.365             0.714910    
ATCTCT      -0.0188312  0.0423727  -0.444             0.656743    
ATCTGT      -0.0546275  0.0413095  -1.322             0.186043    
ATGATG       0.0009513  0.0330499   0.029             0.977038    
ATGCGC      -0.0289324  0.0331970  -0.872             0.383466    
ATGGAA       0.0121842  0.0356755   0.342             0.732708    
ATGGGC       0.1088694  0.0559995   1.944             0.051887 .  
ATGGGT      -0.0461460  0.0502071  -0.919             0.358041    
ATGGTG       0.1335614  0.0477890   2.795             0.005195 ** 
ATGGTT       0.0315913  0.0358271   0.882             0.377905    
ATGTGG       0.1205877  0.0562330   2.144             0.032004 *  
ATGTTT      -0.0011160  0.0285914  -0.039             0.968865    
ATTAGA      -0.1192412  0.0494572  -2.411             0.015913 *  
ATTCCT      -0.0149659  0.0376554  -0.397             0.691043    
ATTCGT      -0.0817359  0.0410821  -1.990             0.046644 *  
ATTCTT      -0.0322920  0.0340860  -0.947             0.343456    
ATTGCC       0.0318242  0.0351346   0.906             0.365057    
ATTGTG       0.1083446  0.0369952   2.929             0.003406 ** 
ATTGTT      -0.0263346  0.0276522  -0.952             0.340923    
ATTTCA       0.0369943  0.0283786   1.304             0.192377    
ATTTGA       0.0288458  0.0319528   0.903             0.366656    
ATTTGC       0.0395107  0.0299031   1.321             0.186410    
ATTTGT       0.0275211  0.0299566   0.919             0.358258    
ATTTTT       0.0055589  0.0191895   0.290             0.772059    
CAAAAA       0.0428849  0.0332410   1.290             0.197015    
CAAAAT       0.0273184  0.0309413   0.883             0.377289    
CAAACA      -0.0517726  0.0382867  -1.352             0.176306    
CAAACC      -0.0111652  0.0453391  -0.246             0.805483    
CAAACT       0.1173320  0.0401261   2.924             0.003456 ** 
CAAAGC      -0.0149532  0.0405287  -0.369             0.712164    
CAAATA       0.0594172  0.0303805   1.956             0.050498 .  
CAAATT      -0.0014698  0.0305009  -0.048             0.961567    
CAACAG       0.0894659  0.0408565   2.190             0.028547 *  
CAACCA      -0.0476060  0.0500942  -0.950             0.341950    
CAACGA      -0.0822138  0.0536444  -1.533             0.125388    
CAAGAA       0.0356044  0.0433301   0.822             0.411250    
CAAGAG       0.0390965  0.0615918   0.635             0.525583    
CAAGGC       0.0307217  0.0598184   0.514             0.607546    
CAAGGT      -0.0376725  0.0538850  -0.699             0.484475    
CACAAA      -0.0496227  0.0389773  -1.273             0.202982    
CACAAT       0.0173282  0.0392292   0.442             0.658697    
CACACA       0.0533106  0.0486460   1.096             0.273133    
CACACT       0.0082194  0.0540850   0.152             0.879210    
CACAGA      -0.0259867  0.0485818  -0.535             0.592718    
CACATG      -0.1503289  0.0501335  -2.999             0.002714 ** 
CACATT      -0.0236562  0.0371988  -0.636             0.524818    
CACCTC       0.0176576  0.0644218   0.274             0.784013    
CACGCT      -0.1483944  0.0597872  -2.482             0.013067 *  
CACGGC      -0.0045647  0.0596433  -0.077             0.938995    
CACGTT      -0.1152615  0.0468792  -2.459             0.013948 *  
CACTAT      -0.0062379  0.0431642  -0.145             0.885095    
CACTCT      -0.0471972  0.0492835  -0.958             0.338236    
CACTGC      -0.0943948  0.0483261  -1.953             0.050792 .  
CACTGG      -0.1428106  0.0501310  -2.849             0.004391 ** 
CAGAAA      -0.0431665  0.0310257  -1.391             0.164137    
CAGAGA      -0.0247082  0.0525077  -0.471             0.637955    
CAGAGT      -0.0841138  0.0522699  -1.609             0.107575    
CAGCAA      -0.0026232  0.0323125  -0.081             0.935297    
CAGCAG      -0.0243111  0.0497447  -0.489             0.625044    
CAGCTC       0.0085107  0.0617543   0.138             0.890386    
CAGGAC      -0.0915517  0.0510952  -1.792             0.073173 .  
CAGGAT       0.0252656  0.0356034   0.710             0.477931    
CAGGCA      -0.0032914  0.0407616  -0.081             0.935644    
CAGTCG      -0.0016126  0.0630713  -0.026             0.979602    
 [ reached getOption("max.print") -- omitted 452 rows ]
---
Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1

Residual standard error: 1.439 on 46929 degrees of freedom
  (5917 observations deleted due to missingness)
Multiple R-squared:  0.034, Adjusted R-squared:  0.0206 
F-statistic: 2.537 on 651 and 46929 DF,  p-value: < 0.00000000000000022

Maybe we can just focus on CRP and try to make a position-specific model. The change in CRP score (let’s say we use an HMM) at each position can be weighted by the average change in expression at the position across the entire library. Or learn the appropriate weights and see how they compare to the average expression change. To do so, compare scrambled to wild-type and note all the k-mers that are different in the scramble and the relative position in the sequence. Link this to change in expression. This input set (position, change in CRP score) and output set (change in expression) can be used for models. Regression?

crp_phmm <- derivePHMM(crp_sites, k = 5)
Deriving profile HMM
Refining model
Iteration 1: alignment with 376 rows & 24 columns, PHMM with 22 modules
Iteration 2: alignment with 376 rows & 24 columns, PHMM with 22 modules
Iteration 3: alignment with 376 rows & 24 columns, PHMM with 22 modules
Error in tmp == hashis : non-conformable arrays

We can view the k-mer change between wild-type and scramble as either a k-mer destroyed in wild-type or a k-mer created in scramble. Let’s go with k-mers that are destroyed in the wild-type.

df <- filter(data, tss_name == 'TSS_10021_storz_wanner_regulondb')
# set wild-type
wt <- filter(df, category == 'unscramble')
wt_seq <- as.character(wt$variant)
vars <- filter(df, category == 'scramble') %>% arrange(scramble_start)
total_phmm_score <- function(seq_list, phmm) {
    forward_path <- lapply(seq_list, forward, x = phmm)
    log_odds <- unlist(lapply(forward_path, `[[`, 1))
    return(sum(log_odds))
}
highest_phmm_match <- function(seq_list, phmm) {
    forward_path <- lapply(seq_list, forward, x = phmm)
    log_odds <- unlist(lapply(forward_path, `[[`, 1))
    index <- which.max(log_odds)
    max_log_odds <- log_odds[index]
    # best_match <- paste(seq_list[[index]], collapse = '')
    return(c(max_log_odds, index))
}
scan_phmms <- function(sequence, phmms, score_type) {
    # generate tiles
    n <- phmms[[1]]$size
    starts <- seq(nchar(sequence) - n + 1)
    tiles <- mapply(substr, start =  starts, stop = starts + n - 1, 
                    MoreArgs = list(x = sequence))
    tiles_list <- strsplit(tiles, split = '')
    if(score_type == 'sum') {
        score <- lapply(phmms, total_phmm_score, seq_list = tiles_list)
    }
    else if(score_type == 'max') {
        score <- lapply(phmms, highest_phmm_match, seq_list = tiles_list)
    }
    return(score)
}
phmms <- list(crp_phmm)
vars <- vars %>% 
    rowwise() %>% 
    mutate(total_crp_phmm_score = unlist(scan_phmms(variant, 
                                                    phmms = phmms, 
                                                    score_type = 'sum')))
wt_score <- unlist(scan_phmms(wt_seq, phmms, score_type = 'sum'))
vars$delta_phmm_score <- vars$total_crp_phmm_score - wt_score

Let’s look at this test example and see how the change in CRP score compares with relative expression (scrambled expression / wild-type expression)

cor.test(vars$relative_exp, vars$delta_phmm_score)

    Pearson's product-moment correlation

data:  vars$relative_exp and vars$delta_phmm_score
t = 1.1325, df = 26, p-value = 0.2678
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 -0.1700137  0.5457475
sample estimates:
      cor 
0.2168154 

Hmm there does seem to be a connection. If the scramble increases the score, expression goes up. The correlation is mild, but it’s not significant here.

vars <- vars %>% 
    mutate(delta_expression = RNA_exp_ave - unscrambled_exp)
ggplot(vars, aes(delta_phmm_score, delta_expression)) + geom_point()

cor.test(log(vars$delta_expression), vars$delta_phmm_score)
NaNs produced

    Pearson's product-moment correlation

data:  log(vars$delta_expression) and vars$delta_phmm_score
t = 1.8939, df = 17, p-value = 0.07538
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 -0.04540256  0.73270737
sample estimates:
      cor 
0.4174148 

Correlation is better with log.

Let’s wrap this all into one function that can be executed on data grouped by TSS name

phmms <- list(crp_phmm)
data <- data %>% 
    rowwise() %>% 
    mutate(total_crp_phmm_score = unlist(scan_phmms(variant, 
                                                    phmms = phmms, 
                                                    score_type = 'sum'))) %>% 
    ungroup()
# calculate difference between scramble and wild-type
data <- data %>% 
    group_by(tss_name) %>% 
    mutate(wt_total_crp_phmm_score = ifelse(any(category == 'unscramble'),
                                            total_crp_phmm_score[category == 'unscramble'],
                                            NA),
           delta_phmm_score = total_crp_phmm_score - wt_total_crp_phmm_score) %>% 
    ungroup()
data <- data %>% 
    mutate(delta_expression = RNA_exp_ave - unscrambled_exp)
ggplot(data, aes(delta_phmm_score, delta_expression)) + geom_point(alpha = 0.25)

cor.test(data$delta_expression, data$delta_phmm_score)

    Pearson's product-moment correlation

data:  data$delta_expression and data$delta_phmm_score
t = 1.4881, df = 47579, p-value = 0.1367
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 -0.002163488  0.015806306
sample estimates:
       cor 
0.00682196 

What if we looked at the difference in the log transformed expression?

tmp <- data %>% 
    mutate(log_exp = log(RNA_exp_ave),
           wt_log_exp = log(unscrambled_exp),
           delta_log_exp = log_exp - wt_log_exp)
cor.test(tmp$delta_log_exp, tmp$delta_phmm_score)

    Pearson's product-moment correlation

data:  tmp$delta_log_exp and tmp$delta_phmm_score
t = 4.4709, df = 47579, p-value = 0.000007805
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 0.01150958 0.02947267
sample estimates:
       cor 
0.02049278 

Hmm, interesting the correlation does improve and is significant now, even though it’s really small.

ggplot(data, aes(as.character(scramble_start), delta_phmm_score)) + geom_boxplot() +
    labs(x = 'scramble start position', y = 'change in CRP score') + 
    theme(axis.text.x = element_text(angle = 45, hjust = 1))

data %>% 
    filter(category == 'scramble') %>% 
    select(scramble_start, delta_phmm_score, delta_expression) %>% 
    lm(delta_expression ~ . , data = .) %>% 
    summary()

Call:
lm(formula = delta_expression ~ ., data = .)

Residuals:
    Min      1Q  Median      3Q     Max 
-49.010   0.025   0.184   0.323  29.380 

Coefficients:
                   Estimate Std. Error t value           Pr(>|t|)    
(Intercept)      -0.1620857  0.0210336  -7.706 0.0000000000000132 ***
scramble_start   -0.0010427  0.0002577  -4.047 0.0000520487610120 ***
delta_phmm_score  0.0022791  0.0016293   1.399              0.162    
---
Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1

Residual standard error: 2.304 on 45782 degrees of freedom
  (5917 observations deleted due to missingness)
Multiple R-squared:  0.000401,  Adjusted R-squared:  0.0003573 
F-statistic: 9.182 on 2 and 45782 DF,  p-value: 0.0001031
data %>% 
    filter(category == 'scramble') %>% 
    mutate(log_exp = log(RNA_exp_ave),
           wt_log_exp = log(unscrambled_exp),
           delta_log_exp = log_exp - wt_log_exp) %>% 
    select(scramble_start, delta_phmm_score, delta_log_exp) %>% 
    lm(delta_log_exp ~ . , data = .) %>% 
    summary()

Call:
lm(formula = delta_log_exp ~ ., data = .)

Residuals:
    Min      1Q  Median      3Q     Max 
-7.6194 -0.2474  0.1032  0.3788  4.2649 

Coefficients:
                    Estimate  Std. Error t value             Pr(>|t|)    
(Intercept)      -0.08997054  0.00718880 -12.515 < 0.0000000000000002 ***
scramble_start   -0.00179039  0.00008807 -20.329 < 0.0000000000000002 ***
delta_phmm_score  0.00234632  0.00055685   4.214            0.0000252 ***
---
Signif. codes:  0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1

Residual standard error: 0.7875 on 45782 degrees of freedom
  (5917 observations deleted due to missingness)
Multiple R-squared:  0.009338,  Adjusted R-squared:  0.009294 
F-statistic: 215.8 on 2 and 45782 DF,  p-value: < 0.00000000000000022

Model is marginally better using log transformed data, which is interesting.

Let’s find the location of the best CRP match for each wild-type sequence.

wt_sequences <- as.list(filter(data, category == 'unscramble') %>% .$variant)
wt_phmm_hits <- lapply(wt_sequences, scan_phmms, phmms = phmms, score_type = 'max')
# unlist the sublists
wt_phmm_hits <- lapply(wt_phmm_hits, unlist)

Now that we know where the best CRP site is for each WT, let’s create a new data frame that lists, for each WT sequence, the scrambled variants that overlap the site and the change in expression between WT and scrambled.

# source("http://bioconductor.org/biocLite.R")
# biocLite("IRanges")
library(IRanges)
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: ‘BiocGenerics’

The following objects are masked from ‘package:parallel’:

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ, clusterExport, clusterMap,
    parApply, parCapply, parLapply, parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from ‘package:dplyr’:

    combine, intersect, setdiff, union

The following objects are masked from ‘package:stats’:

    IQR, mad, sd, var, xtabs

The following objects are masked from ‘package:base’:

    anyDuplicated, append, as.data.frame, basename, cbind, colMeans, colnames, colSums,
    dirname, do.call, duplicated, eval, evalq, Filter, Find, get, grep, grepl, intersect,
    is.unsorted, lapply, lengths, Map, mapply, match, mget, order, paste, pmax, pmax.int,
    pmin, pmin.int, Position, rank, rbind, Reduce, rowMeans, rownames, rowSums, sapply,
    setdiff, sort, table, tapply, union, unique, unsplit, which, which.max, which.min

Loading required package: S4Vectors
Loading required package: stats4

Attaching package: ‘S4Vectors’

The following object is masked from ‘package:tidyr’:

    expand

The following objects are masked from ‘package:dplyr’:

    first, rename

The following object is masked from ‘package:base’:

    expand.grid


Attaching package: ‘IRanges’

The following objects are masked from ‘package:dplyr’:

    collapse, desc, slice
# assign position relative to TSS and with respect to strand
wt_df <- wt_df %>% 
    mutate(wt_best_crp_score_pos_relative = case_when(.$strand == '+' ~ wt_best_crp_score_pos - 121,
                                                      .$strand == '-' ~ 150 - wt_best_crp_score_pos - 120,
                                                      TRUE ~ NaN))
ggplot(wt_df, aes(factor(wt_best_crp_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 8)) +
    labs(x = 'start position of best WT CRP site',
         y = 'log expression scramble - \n log expression WT')

cor.test(wt_df$wt_best_crp_score_pos_relative, wt_df$delta_log_exp)

    Pearson's product-moment correlation

data:  wt_df$wt_best_crp_score_pos_relative and wt_df$delta_log_exp
t = 0.68491, df = 8412, p-value = 0.4934
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 -0.01390249  0.02883056
sample estimates:
        cor 
0.007467443 

Not all of the WT sequences are actually regulated by CRP and could be contributing noise. Let’s assign a significance to each CRP score and filter out sequences that do not have strong sites. Let’s take a random sample of the genome and plot the distribution of CRP HMM scores.

bedtools random -l 22 -n 10000 -seed 123 -g ../../ref/Escherichia_coli_K-12_MG1655_genomeFile.txt > ecoli_genome_random_22bp.bed
bedtools getfasta -fi ../../ref/Escherichia_coli_K-12_MG1655.fasta -bed ecoli_genome_random_22bp.bed -fo ecoli_genome_random_22bp.txt -tab -s
genome_random <- read.table('ecoli_genome_random_22bp.txt', header = F,
                            col.names = c('name', 'sequence'))
random_sequences <- strsplit(genome_random$sequence, '')
random_phmm_hits <- lapply(random_sequences, forward, x = crp_phmm)
# extract just score
random_phmm_hits <- unlist(lapply(random_phmm_hits, `[[`, 1))
ggplot(data.frame(score = random_phmm_hits), aes(score)) + geom_density() +
    labs(x = 'CRP HMM score', title = '100,000 random genomic sequences 22bp')

Calculate permutation p-value: B / m B : how many observations from the random genomic distribution have a value at least as extreme m: number of tests

This can also be thought of as 1 - percentile. Example, 20% percentile is value below which 20% of observations may be found.

random_hits_ecdf <- ecdf(random_phmm_hits)
wt_df <- wt_df %>% 
    mutate(emp_pval = 1 - random_hits_ecdf(wt_best_crp_score))
ggplot(wt_df, aes(wt_best_crp_score)) + geom_density()

ggplot(wt_df, aes(emp_pval)) + geom_density() + 
    geom_vline(xintercept = 0.05, color = 'red')

It seems like the distribution of CRP scores for our library is much different than the genomic distribution. Maybe promoters in general are more likely to have at least one high scoring CRP site compared to random genomic sequence (which would fall in genes too). So, most of these WT sequences would have a significant CRP site with this current “null” genomic distribution. Or, maybe scanning the 150bp chunks with the 22bp HMM is just much more sampling, so more likely to get a higher score. Let’s grab 150bp random chunks from the genome and see if it changes anything.

bedtools random -l 150 -n 10000 -seed 123 -g ../../ref/Escherichia_coli_K-12_MG1655_genomeFile.txt > ecoli_genome_random_150bp.bed
bedtools getfasta -fi ../../ref/Escherichia_coli_K-12_MG1655.fasta -bed ecoli_genome_random_150bp.bed -fo ecoli_genome_random_150bp.txt -tab -s
genome_random150 <- read.table('ecoli_genome_random_150bp.txt', header = F,
                            col.names = c('name', 'sequence'))
random150_sequences <- as.list(genome_random150$sequence)
random150_phmm_hits <- lapply(random150_sequences, scan_phmms, phmms = phmms, score_type = 'max')
# unlist
random150_phmm_hits <- lapply(random150_phmm_hits, `[[`, 1)
random150_phmm_hits_score <- unlist(lapply(random150_phmm_hits, `[[`, 1))
ggplot(data.frame(score = random150_phmm_hits_score), aes(score)) + geom_density() +
    labs(x = 'CRP HMM score', title = '100,000 random genomic sequences 150bp') +
    geom_density(data = wt_df, aes(wt_best_crp_score), color = 'red')

random_hits_ecdf <- ecdf(random150_phmm_hits_score)
wt_df <- wt_df %>% 
    mutate(emp_pval = 1 - random_hits_ecdf(wt_best_crp_score))
ggplot(wt_df, aes(emp_pval)) + geom_density() + 
    geom_vline(xintercept = 0.05, color = 'red')

Much better!

wt_df_crp <- filter(wt_df, emp_pval <= .05)
table(wt_df_crp$category)

  scramble unscramble 
       992        270 
table(data$category)

  scramble unscramble 
     51702       1796 

About 15% of WT (unscrambled) sequences contain a CRP site with an empirical p-value of 0.05.

Let’s look at the start position of the WT best CRP score vs. change in logged expression for only the WTs (and their overlapping scrambled variants) with significant CRP sites.

ggplot(wt_df_crp, aes(factor(wt_best_crp_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 10)) +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    labs(x = 'start position of best WT CRP site',
         y = 'log expression scramble - \n log expression WT',
         title = 'WT with significant CRP site')

wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp),
              n = n()) %>% 
    ggplot(aes(score_fact, mean_delta)) + geom_bar(stat = 'identity') +
    theme(axis.text.x = element_text(angle = 90, size = 10)) +
    labs(x = 'start position of best WT CRP site',
         y = 'mean(log expression scramble - \n log expression WT)')

wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact))) %>% 
    ggplot(aes(pos, mean_delta)) + geom_point() + 
    # geom_smooth(span = 0.1) + 
    geom_line() +
    geom_hline(yintercept = 0, linetype = 'dashed')

Let’s get the mean change in log expression at each position, before we filter out for CRP significance. Then, we can normalize to this number to account for any positions that are sensitive to scrambling in general.

wt_df_mean_pos <- wt_df %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta_all = mean(delta_log_exp))
wt_df_crp_mean_pos <- wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp))
wt_df_mean_pos_all <- full_join(wt_df_mean_pos, wt_df_crp_mean_pos, by = 'score_fact') %>% 
    mutate(mean_delta_norm = mean_delta - mean_delta_all,
           score_fact = factor(score_fact))
Column `score_fact` joining factors with different levels, coercing to character vector
ggplot(wt_df_mean_pos_all, aes(reorder(score_fact, sort(as.numeric(score_fact))), mean_delta_norm)) + geom_bar(stat = 'identity') +
    theme(axis.text.x = element_text(angle = 90, size = 10)) +
    labs(x = 'start position of best WT CRP site',
         y = 'normalized mean(log expression scramble - \n log expression WT)')

Looks almost the same, even after subtracting the average expression change for all WT sequences (including those that didn’t pass CRP filter).

Let’s put all of this functionality in one place, so we can generate these graphs for a TF of our choice.

    phmm <- derivePHMM(sites_filtered, k = 5)
Deriving profile HMM
Refining model
Iteration 1: alignment with 104 rows & 15 columns, PHMM with 15 modules
Sequential alignments were identical after 1 iterations
Done
tf <- 'Fis'
wt_df_fis <- score_tf_phmm(tf, tf_sites, data, random150_sequences)
Deriving profile HMM
Refining model
Iteration 1: alignment with 243 rows & 15 columns, PHMM with 15 modules
Sequential alignments were identical after 1 iterations
Done
[1] "All TF hits in WT: 53502"
[1] "All significant TF hits in WT: 1204"
ggplot(wt_df_fis, aes(factor(wt_best_tf_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 8)) +
    labs(x = paste('start position of best WT', tf, 'site'),
         y = 'log expression scramble - \n log expression WT')

wt_df_fis %>% 
    mutate(score_fact = factor(wt_best_tf_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact))) %>% 
    ggplot(aes(pos, mean_delta)) + geom_point() + 
    # geom_smooth(span = 0.1) + 
    geom_line() +
    geom_hline(yintercept = 0, linetype = 'dashed')

crp_mean_line <- wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact)))
fis_mean_line <- wt_df_fis %>% 
    mutate(score_fact = factor(wt_best_tf_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact)))
ggplot(aes(pos, mean_delta), data=crp_mean_line) + geom_point() + 
    # geom_smooth(span = 0.1) + 
    geom_line() +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    geom_line(aes(pos, mean_delta), data=fis_mean_line, color='blue') +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'log expression scramble - \n log expression WT')

ggplot(aes(pos, mean_delta), data=crp_mean_line) + 
    geom_smooth(span = 0.1, color='black') +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'mean log expression scramble - \n log expression WT',
         title = 'WT with significant CRP site')

ggplot(aes(pos, mean_delta), data=crp_mean_line) + 
    geom_smooth(span = 0.1, color='black') +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    geom_smooth(aes(pos, mean_delta), data=fis_mean_line, color='blue', span=0.1) +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'mean log expression scramble - \n log expression WT')

tf <- 'ArcA'
wt_df_arca <- score_tf_phmm(tf, tf_sites, data, random150_sequences)
Deriving profile HMM
Refining model
Iteration 1: alignment with 104 rows & 15 columns, PHMM with 15 modules
Sequential alignments were identical after 1 iterations
Done
[1] "All TF hits in WT: 53502"
[1] "All significant TF hits in WT: 0"
ggplot(wt_df_arca, aes(factor(wt_best_tf_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 8)) +
    labs(x = paste('start position of best WT', tf, 'site'),
         y = 'log expression scramble - \n log expression WT')

arca_mean_line <- wt_df_arca %>% 
    mutate(score_fact = factor(wt_best_tf_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact)))
ggplot(aes(pos, mean_delta), data=fis_mean_line)  + 
    geom_smooth(span = 0.1, color='blue') +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    geom_smooth(aes(pos, mean_delta), data=arca_mean_line, color='red', span=0.1) +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'log expression scramble - \n log expression WT')

---
title: "Endo TSS scramble exploration"
output: html_notebook
---

```{r, include = F, mesage = F}
options(scipen = 10000)
options(stringsAsFactors = F)

library(dplyr)
library(tidyr)
library(ggplot2)
library(cowplot)
library(kmer)
library(aphid)
library(Biostrings)

setwd("~/Documents/projects/ecoli_promoters/endo/scripts/endo_scramble")

data_all <- read.table('../../processed_data/endo_scramble/endo_scramble_expression.txt',
                       header = T)
```

Let's format the names

```{r}
data_all  <- data_all  %>% 
    mutate(name = gsub('_flipped', '', name),
           name = gsub('_rc', '', name))

data_all <- data_all %>% 
    mutate(category = case_when(grepl('unscrambled', .$name) ~ 'unscramble',
                                grepl('neg', .$name) ~ 'negative',
                                TRUE ~ 'scramble'))

table(data_all$category)

data <- filter(data_all, category != 'negative')
data <- data %>% 
    separate(name, into = c('tss_name', 'tss_position', 'strand_scramble_loc'), sep = ',',
             convert = T, remove = F) %>% 
    separate(strand_scramble_loc, into = c('strand', 'scramble_loc'), sep = '_') %>% 
    mutate(scramble_loc = gsub('unscrambled', NA, scramble_loc),
           scramble_loc = gsub('scrambled', '', scramble_loc)) %>% 
    separate(scramble_loc, into = c('scramble_start', 'scramble_end'),
             sep = '-', convert = T)
```

```{r}
example <- filter(data, tss_name == 'TSS_2716_regulondb')
ggplot(example, aes(scramble_start, RNA_exp_ave)) + geom_point()+
    labs(x = 'scramble start position (length 10bp)', y = 'expression')
```

```{r}
negatives <- filter(data_all, category == 'negative')
neg_median <- median(negatives$RNA_exp_ave)
threshold <- 2 * neg_median

example <- example %>% 
    mutate(active = ifelse(RNA_exp_ave >= threshold, 'active', 'inactive'))

ggplot(example, aes(scramble_start, RNA_exp_ave)) + geom_point(aes(color = active)) +
    scale_color_manual(values = c('red', 'black')) +
    labs(x = 'scramble start position (length 10bp)', y = 'expression', color = '')
```

```{r}
ggplot(data, aes(scramble_start, RNA_exp_ave)) + geom_point() +
    labs(x = 'scramble start position (length 10bp)', 'expression') +
    scale_y_log10()
```

Let's calculate the expression of each scrambled sequence relative to the unscrambled sequence
```{r}
data <- data %>% 
    group_by(tss_name) %>% 
    mutate(unscrambled_exp = ifelse(any(category == 'unscramble'),
                                 RNA_exp_ave[category == 'unscramble'],
                                 NA),
           relative_exp = RNA_exp_ave / unscrambled_exp)

data <- data %>% 
    mutate(active = ifelse(RNA_exp_ave >= threshold, 'active', 'inactive'))
```

```{r}
data %>% 
    ggplot(aes(scramble_start, relative_exp)) + geom_point(aes(color = active)) +
    scale_color_manual(values = c('red', 'black')) +
    scale_y_log10() +
    labs(x = 'scramble start', y= 'relative expression', color = '')
```

```{r}
data %>% 
    filter(tss_name == 'TSS_2716_regulondb') %>% 
    ggplot(aes(scramble_start, relative_exp)) + geom_point(aes(color = active)) +
    scale_color_manual(values = c('red', 'black')) +
    scale_y_log10() + geom_hline(yintercept = 1, linetype = 'dashed') +
    labs(x = 'scramble start', y= 'relative expression', color = '')
```

```{r}
data %>%
    mutate(active_relative = ifelse(relative_exp >= 1, 'active', 'inactive')) %>% 
    group_by(active_relative) %>% 
    tally()
```

Only 68% of the library was mapped, so it seems many sequences are missing their unscrambled counterpart. After the next mapping run, we should get most of the library mapped. It's probably best to classify each sequence as inactive/active relative to their unscrambled sequence. Anything with less expression than unscrambled will be "inactive"
and anything higher as "active".

```{r}
corr <- cor(data$RNA_exp_1, data$RNA_exp_2)
ggplot(data, aes(RNA_exp_1, RNA_exp_2)) + geom_point() + 
    scale_x_log10() + scale_y_log10() + annotation_logticks(sides = 'bl') +
    labs(x = 'biological replicate 1', y = 'biological replicate 2') +
    annotate('text', x = 10, y = 0.1, label = paste0('r = ', signif(corr, 3)), size = 6)
```


Which k-mers are enriched in the active vs. inactive sequences?
If the scrambled sequence has increased expression relative to unscrambled, we assume it is
disrupting a repressive element. If the scrambled sequence has decreased expression
relative to unscrambled, we assume it is disrupting an activating element. 

```{r, include = F}
library(Biostrings)
increased_set <- DNAStringSet(filter(data, relative_exp > 1)$variant)
decreased_set <- DNAStringSet(filter(data, relative_exp < 1)$variant)

k <- 6
# collapse to get counts for the entire set, not just by sequence
increased_kmer_freq <- colSums(oligonucleotideFrequency(increased_set, width = k))
decreased_kmer_freq <- colSums(oligonucleotideFrequency(decreased_set, width = k))
```

```{r}
bases <- c('A', 'T', 'G', 'C')
possible_kmers <- gtools::permutations(n = length(bases),
                                       v = bases, 
                                       r = k,
                                       repeats.allowed = T)
possible_kmers <- apply(possible_kmers, 1, paste, collapse='')

total_kmers_increased <- (150 - k + 1) * length(increased_set)
total_kmers_decreased <- (150 - k + 1) * length(decreased_set)

kmer_fisher <- function(kmer, df1, df2, df1_total, df2_total) {
    df1_count <- df1[kmer]
    df2_count <- df2[kmer]
    mat <-matrix(c(df1_count, df2_count,
                   df1_total - df1_count, 
                   df2_total - df2_count), nrow = 2)
    test <- fisher.test(mat)
    return(test)
}

tests <- mapply(kmer_fisher,
                kmer = possible_kmers,
                MoreArgs = list(
                    df1 = increased_kmer_freq,
                    df2 = decreased_kmer_freq,
                    df1_total = total_kmers_increased,
                    df2_total = total_kmers_decreased))
tests <- as.data.frame(t(tests))
tests$kmer <- rownames(tests)
tests <- tests %>% 
    mutate(p.value = as.numeric(p.value),
           estimate = as.numeric(estimate),
           p.value.adjusted = p.adjust(tests$p.value, method = 'fdr'))

signif_kmers_fdr <- tests %>% 
    filter(p.value.adjusted <= 0.05) %>% 
    arrange(p.value.adjusted) %>% 
    select(kmer, p.value, p.value.adjusted, estimate)

signif_kmers_fdr <- signif_kmers_fdr %>% 
    mutate(kmer_rc =
               as.character(Biostrings::reverseComplement(
                   DNAStringSet(signif_kmers_fdr$kmer)))) %>% 
    select(kmer, kmer_rc, p.value:estimate)

signif_kmers_fdr %>% 
    filter(estimate < 1) %>% nrow()

signif_kmers_fdr %>% 
    filter(estimate > 1) %>% nrow
```

Do these k-mer match any TF PWMs for E. coli?

```{r}
# http://regulondb.ccg.unam.mx/menu/download/datasets/files/BindingSiteSet.txt
tf_sites <- read.table('../../ref/regulondb_tfbs.txt', comment.char = '#',
                       header = F, sep = '\t',
                       col.names = c('tf_id', 'tf_name', 'tfbs_id', 'tfbs_left',
                                     'tfbs_right', 'strand', 'tf_gene_id', 'tx_unit',
                                     'expression_effect', 'promoter_name',
                                     'center_pos_relative_tss', 'tfbs_sequence',
                                     'evidence', 'evidence_confidence'))

# extract TFBS from sequence, in upper case
# grab upper case part of site corresponding to binding site
extract_upper <- function(string, toString) {
    replace_lower <- strsplit(string, "[[:lower:]]*")[[1]]
    only_upper <- replace_lower[replace_lower != ""]
    if(toString == T) {
        return(paste(only_upper, collapse = ''))
    }
    else{
        return(only_upper)
    }
}

tf_sites$tfbs <- unlist(lapply(tf_sites$tfbs_sequence, extract_upper, toString = T))

signif_kmers_fdr <- signif_kmers_fdr %>% 
    group_by(kmer) %>% 
    mutate(tf_match_most_common = ifelse(any(grep(kmer, tf_sites$tfbs)),
                                         names(which.max(table(tf_sites$tf_name[grep(kmer,
                                                                                     tf_sites$tfbs)]))),
                                         NA),
           num_tf_match_most_common = ifelse(any(grep(kmer, tf_sites$tfbs)),
                                             max(table(tf_sites$tf_name[grep(kmer, tf_sites$tfbs)])),
                                             NA)) %>% 
    ungroup()

signif_kmers_fdr <- signif_kmers_fdr %>% 
    mutate(kmer_type = ifelse(estimate > 1, 'enriched', 'depleted'))

tf_counts <- signif_kmers_fdr %>% 
    group_by(kmer_type, tf_match_most_common) %>% 
    tally() %>% 
    arrange(desc(n))
```



```{r}
tf_counts %>% 
    filter(n >= 10, !is.na(tf_match_most_common)) %>% 
    ggplot(aes(reorder(tf_match_most_common, n), n)) + 
    geom_bar(aes(fill = kmer_type), stat = 'identity', position = 'dodge') +
    scale_fill_manual(values = c('darkred', 'darkgreen')) +
    theme(axis.text.x = element_text(angle = 45, hjust = 1, size = 10)) +
    labs(x = 'TF', y = 'number of matching k-mers', fill = '')
    
```

Most common TF is CRP, cAMP-activated global transcriptional regulator, which makes sense. Directly regulates transcription
of ~300 genes in about 200 operons, indirectly regulates expression of about half the genome.

Next most common is Fis, DNA-binding protein Fis. Activates ribosomal RNA transcription, as well as other genes. Plays
direct role in upstream activation of rRNA promoters. 

Lrp, leucine-responsive regulatory protein. Mediates global response to leucine. 

NarL, nitrate/nitrite response regulator protein, activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.

Instead of doing an exact match between the k-mer and the TFBS, let's create an HMM for each
TF and use that to score each k-mer.

```{r}
create_phmm <- function(df, tf, n_iter = 10, verbose = F) {
    seq_list <- strsplit(toupper(filter(df, tf_name == tf)$tfbs), split = '')
    # for some reason, maybe the way the sequences are randomly aligned, the same
    # exact command will fail multiple times and then suceed. So, just keep trying
    # until it works
    phmm <- NULL
    attempt <- 0
    while(is.null(phmm) && attempt < n_iter) {
        attempt <- attempt + 1
        try (
            phmm <- derivePHMM(seq_list, maxsize = max(unlist(lapply(seq_list, length))), quiet = !verbose),
            silent = T
        )
    }
    if(attempt > 1) {
        print(paste("Number of attempts for", tf, ":", attempt))
    }
    if(is.null(phmm)) {
        return(NA)
    }
    else{
        return(phmm)
    }
}

tf_sites_with_sequence <- filter(tf_sites, tfbs != '')
tf_list <- as.list(unique(tf_sites_with_sequence$tf_name))
tf_phmms <- lapply(tf_list, create_phmm, df = tf_sites_with_sequence)
names(tf_phmms) <- unlist(tf_list)
```

```{r}
# let's try to get missing TF
missing_tfs <- tf_list[is.na(tf_phmms)]
missing_phmms <- lapply(missing_tfs, create_phmm, df = tf_sites_with_sequence, n_iter = 20)
```

Why is this happening? Let's take Fis as an example.

```{r}
fis_sites <- filter(tf_sites_with_sequence, tf_name == 'Fis')$tfbs
fis_seq_list <- strsplit(toupper(fis_sites), split = '')
derivePHMM(fis_seq_list)
```

The initial alignment attempt has 52 columns, and maybe the multiple
sequence alignment is just too unstable. Is there varying binding site lengths?

```{r}
fis_site_lengths <- unlist(lapply(fis_seq_list, length))
table(fis_site_lengths)
```

Let's only keep sites that are the predominant 15bp and see if this helps.

```{r}
fis_seq_list_trimmed <- fis_seq_list[fis_site_lengths == 15]
derivePHMM(fis_seq_list_trimmed)
```

If you trim the binding sites to only include 15bp, it works perfectly fine.

```{r}
filter(tf_sites_with_sequence, tf_name %in% missing_tfs) %>% 
    mutate(tfbs_length = nchar(tfbs)) %>% 
    group_by(tf_name) %>% 
    mutate(num_lengths = n_distinct(tfbs_length)) %>% 
    distinct(tf_name, num_lengths) %>% 
    ggplot(aes(x = tf_name, y = num_lengths)) + geom_bar(stat = 'identity') +
    labs(x = 'TF', y = 'number of distinct binding site lengths',
         title = 'TFs that failed to generate PHMMs') +
    scale_y_continuous(breaks = seq(1:10))
```

Hmm at least for the TFs that we couldn't generate PHMMs, they all have at least two
different binding site lengths. How true is this for all TFs?

```{r}
tf_sites_with_sequence %>% 
    mutate(tfbs_length = nchar(tfbs),
           missing_phmm = ifelse(tf_name %in% missing_tfs, T, F)) %>% 
    group_by(tf_name) %>% 
    mutate(num_lengths = n_distinct(tfbs_length)) %>% 
    distinct(tf_name, num_lengths, missing_phmm) %>% 
    ggplot(aes(num_lengths, fill = missing_phmm)) + geom_histogram(binwidth = 1) +
    labs(x = 'number of distinct binding site lengths', title = 'All TFs',
         fill = 'missing PHMM') +
    scale_x_continuous(breaks = seq(1:10))
```

Let's see if there's a way to tweak the alignment parameters before we just start
eliminating sites.

```{r}
index_trimmed <- fis_site_lengths[fis_site_lengths == 15]
derivePHMM(fis_seq_list, progressive = T, seeds = which(fis_site_lengths == 15)[1:25], maxsize=15)
```


Actually, let's just use the position specific scoring matrices from RegulonDBs, 
then convert to PWMs.

```{bash}
python parse_regulondb_pssm.py ../../ref/regulondb_tf_pssm.txt regulondb_tf_pssm_parsed.txt
```

```{r}
library(PWMEnrich)
tf_pssm_raw <- read.table('regulondb_tf_pssm_parsed.txt',
                      col.names = c('tf_name', 'position', 'A', 'C', 'G', 'T'))

create_pfm <- function(df, tf) {
    pfm <- data.matrix(filter(df, tf_name == tf) %>% select(-tf_name, -position))
    pfm <- t(pfm)
    return(pfm)
}

tf_names <- as.list(unique(tf_pssm_raw$tf_name))
pfm_list <- lapply(tf_names, create_pfm, df = tf_pssm_raw)
pwm_list <- PFMtoPWM(pfm_list, id = as.character(tf_names))
```

This actually won't work because PWMs require the k-mer is at least as long as the PWM.
Since we're using 6-kmers and most PWMs are longer, this is a problem. Back to using PHMMs!


Let's look at what k-mers are associated with relative expression, using simple linear regression.
We only care about the significant ones.

```{r}
kmer_counts <- kcount(x = strsplit(data$variant, split = ''), k = 6, residues = 'DNA')
kmer_counts_df <- data.frame(kmer_counts)
kmer_counts_df$expression <- data$relative_exp
```

Let's first try individual linear regression for each k-mer and see how many are significant.

```{r}
individ_kmer_reg <- function(kmer, kmer_counts_df) {
    counts <- select(kmer_counts_df, kmer, expression)
    model <- lm(log(expression) ~ ., counts)
    summary <- summary(model)
    # if k-mer count is too low, lm will return NA for coefficient
    if(nrow(summary$coefficients) == 2) {
        # get coefficient
        coeff <- summary$coefficients[2, 1]
        # get p-value of coefficient
        pval <- summary$coefficients[2, 4]
        return(list(c(coeff, pval)))
    }
    else {
        return(list(c(NA, NA)))
    }
}

# all_kmers <- as.list(colnames(kmer_counts))
# kmer_regression <- lapply(all_kmers, individ_kmer_reg, kmer_counts_df = kmer_counts_df)
# kmer_regression <- data.frame(matrix(unlist(kmer_regression), nrow = length(kmer_regression), byrow=T))
# colnames(kmer_regression) <- c('coeff', 'pval')
# kmer_regression$kmer <- unlist(all_kmers)
# save(kmer_regression, file = 'kmer_regression.rda')
load('kmer_regression.rda')
```

```{r}
ggplot(kmer_regression, aes(log(pval))) + geom_histogram() +
    geom_vline(xintercept = log(0.05), col = 'red') +
    labs(x = 'log10(p-value) of linear regression coefficient',
         title = 'Individual linear regression between\n k-mer and expression')
```

```{r}
signif_kmers_lm_fdr <- kmer_regression %>% 
    mutate(pval_fdr  = p.adjust(pval, method = 'fdr')) %>% 
    filter(pval_fdr <= 0.05)

print(nrow(signif_kmers_lm_fdr))
```
 
 K-mers to the left are significant.

```{r}
# model_all_kmers <- lm(log(expression) ~ . , kmer_counts_df)
# saveRDS(model_all_kmers, file = 'model_all_kmers.rds', compress = T)
model_all_kmers <- readRDS('model_all_kmers.rds')
summary(model_all_kmers)
```

Let's see how many significant k-mers from individual linear regression
compared to those from Fisher test enrichments.

```{r}
coeff <- summary(model_all_kmers)$coefficients
coeff <- coeff[-1,]
signif_kmers_multiple_lm <- unlist(dimnames(coeff)[1][coeff[,4] <= 0.05])
# how many significant in both?
signif_kmers_overlap <- signif_kmers_fdr %>% 
    left_join(data.frame(kmer = signif_kmers_multiple_lm, lm_coeff = coeff[,1], lm_pval = coeff[,4]), 
              by = 'kmer') %>% 
    filter(!is.na(lm_coeff))
print(nrow(signif_kmers_overlap) / nrow(signif_kmers_fdr))
```

Good, most of them. How do the direction of their effects compare?

```{r}
ggplot(signif_kmers_overlap, aes(estimate, lm_coeff)) + geom_point() + 
    labs(x = 'Fisher test estimate', y = 'lm coefficient') + 
    geom_hline(yintercept = 0, linetype = 'dashed') + 
    geom_vline(xintercept = 1, linetype = 'dashed')
```

Hmm they don't always match up, I'll go with the linear regression more than the Fisher
because it doesn't have any classification into "active" or "inactive" and is just based
on the relative expression value.

Let's take a quick look at the coefficients.

```{r}
ggplot(signif_kmers_lm_fdr, aes(coeff)) + geom_density() +
    labs(x = 'linear regression coefficient',
         title = 'All significant k-mers FDR 5%')
```


What are these k-mers? Do they hit TFs?

```{r}
signif_kmers_lm_fdr <- signif_kmers_lm_fdr %>% 
    group_by(kmer) %>% 
    mutate(tf_match_most_common = ifelse(any(grep(kmer, tf_sites$tfbs)),
                                         names(which.max(
                                             table(
                                                 tf_sites$tf_name[grep(kmer, tf_sites$tfbs)])
                                             )), 
                                         NA)
    )
```

```{r}
signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    tally() %>% 
    arrange(desc(n)) %>% 
    filter(n >= 10, !is.na(tf_match_most_common)) %>%
    ggplot(aes(reorder(tf_match_most_common, n), n)) + 
    geom_bar(stat = 'identity', position = 'dodge') +
    scale_fill_manual(values = c('darkred', 'darkgreen')) +
    theme(axis.text.x = element_text(angle = 45, hjust = 1, size = 8)) +
    labs(x = 'TF', y = 'number of matching\n significant k-mers', 
         title = 'Significant k-mers from individual linear regression\n matched to TFBSs')
```

What are the range of coefficients for each TF?

```{r}
signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    summarise(num_kmers = n(),
              mean_coeff = mean(coeff)) %>% 
    ungroup() %>% 
    left_join(signif_kmers_lm_fdr, ., by = 'tf_match_most_common') %>% 
    filter(num_kmers >= 3, !is.na(tf_match_most_common)) %>% 
    ggplot(aes(reorder(tf_match_most_common, mean_coeff), coeff)) + geom_boxplot() +
    geom_hline(yintercept = 0, linetype = 'dashed') +
        theme(axis.text.x = element_text(angle = 90, size = 8)) +
        labs(x = 'linear regression coefficient',
             title = 'All significant k-mers FDR 5% \n(ordered by mean coefficient)')
```

```{r}
signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    summarise(num_kmers = n(),
              mean_coeff = mean(coeff)) %>% 
    ungroup() %>% 
    left_join(signif_kmers_lm_fdr, ., by = 'tf_match_most_common') %>% 
    filter(num_kmers >= 3, !is.na(tf_match_most_common)) %>% 
    ggplot(aes(reorder(tf_match_most_common, num_kmers), coeff)) + geom_boxplot() +
    geom_hline(yintercept = 0, linetype = 'dashed') +
        theme(axis.text.x = element_text(angle = 90, size = 8)) +
        labs(x = 'linear regression coefficient',
             title = 'All significant k-mers FDR 5% \n(ordered by number of significant k-mers)')
```

Negative coefficients implies k-mer count is inversely correlated with expression. 
Positive coefficeints implies k-mer count is positively correlated with expression. For example,


Let's run multiple regression again but with only the significant k-mers.

```{r}
kmer_counts_signif <- select_(kmer_counts_df, .dots = signif_kmers_lm_fdr$kmer)
kmer_counts_signif$expression <- kmer_counts_df$expression
model_signif_kmers <- lm(log(expression) ~ . , kmer_counts_signif)
summary(model_signif_kmers)
```

Hmm, the model does worse, which isn't too surprising since we remove a lot of variables.

```{r}
signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    summarise(n = n()) %>% 
    arrange(desc(n))
```

Let's take k-mers that match to top 5 TFs and see what this small model looks like.

```{r}
top_tfs <- signif_kmers_lm_fdr %>% 
    group_by(tf_match_most_common) %>% 
    summarise(n = n()) %>% 
    arrange(desc(n)) %>% 
    top_n(5) %>% .$tf_match_most_common


kmer_tf_subset <- select_(kmer_counts_df, .dots = 
                              filter(signif_kmers_lm_fdr, tf_match_most_common %in% top_tfs) %>% .$kmer)
kmer_tf_subset$expression <- kmer_counts_df$expression
model_tf_subset <- lm(expression ~ . , kmer_tf_subset)
summary(model_tf_subset)
```

Maybe we can just focus on CRP and try to make a position-specific model. The change in 
CRP score (let's say we use an HMM) at each position can be weighted by the average
change in expression at the position across the entire library. Or learn the appropriate weights and see how they compare to the average expression change. To do so, compare scrambled to wild-type and note all the k-mers that are different in the scramble and the relative position in the sequence. Link this to change in expression. This input set (position, change in CRP score) and output set (change in expression) can be used for models. Regression?

```{r}
library(aphid)

crp_sites_raw <- filter(tf_sites, tf_name == 'CRP', tfbs_sequence != '') %>% .$tfbs_sequence
crp_sites <- lapply(crp_sites_raw, extract_upper, toString = F)
crp_phmm <- derivePHMM(crp_sites, k = 5)
```

We can view the k-mer change between wild-type and scramble as either a k-mer destroyed
in wild-type or a k-mer created in scramble. Let's go with k-mers that are destroyed in the wild-type.

```{r}
df <- filter(data, tss_name == 'TSS_10021_storz_wanner_regulondb')
# set wild-type
wt <- filter(df, category == 'unscramble')
wt_seq <- as.character(wt$variant)
vars <- filter(df, category == 'scramble') %>% arrange(scramble_start)
```

```{r}
total_phmm_score <- function(seq_list, phmm) {
    forward_path <- lapply(seq_list, forward, x = phmm)
    log_odds <- unlist(lapply(forward_path, `[[`, 1))
    return(sum(log_odds))
}


highest_phmm_match <- function(seq_list, phmm) {
    forward_path <- lapply(seq_list, forward, x = phmm)
    log_odds <- unlist(lapply(forward_path, `[[`, 1))
    index <- which.max(log_odds)
    max_log_odds <- log_odds[index]
    # best_match <- paste(seq_list[[index]], collapse = '')
    return(c(max_log_odds, index))
}

scan_phmms <- function(sequence, phmms, score_type) {
    # generate tiles
    n <- phmms[[1]]$size
    starts <- seq(nchar(sequence) - n + 1)
    tiles <- mapply(substr, start =  starts, stop = starts + n - 1, 
                    MoreArgs = list(x = sequence))
    tiles_list <- strsplit(tiles, split = '')
    if(score_type == 'sum') {
        score <- lapply(phmms, total_phmm_score, seq_list = tiles_list)
    }
    else if(score_type == 'max') {
        score <- lapply(phmms, highest_phmm_match, seq_list = tiles_list)
    }
    return(score)
}

phmms <- list(crp_phmm)
vars <- vars %>% 
    rowwise() %>% 
    mutate(total_crp_phmm_score = unlist(scan_phmms(variant, 
                                                    phmms = phmms, 
                                                    score_type = 'sum')))

wt_score <- unlist(scan_phmms(wt_seq, phmms, score_type = 'sum'))
vars$delta_phmm_score <- vars$total_crp_phmm_score - wt_score
```

Let's look at this test example and see how the change in CRP score compares with
relative expression (scrambled expression / wild-type expression)

```{r}
ggplot(vars, aes(delta_phmm_score, relative_exp)) + geom_point()
```


```{r}
cor.test(vars$relative_exp, vars$delta_phmm_score)
```

Hmm there does seem to be a connection. If the scramble increases the score, expression goes up.
The correlation is mild, but it's not significant here.

```{r}
vars <- vars %>% 
    mutate(delta_expression = RNA_exp_ave - unscrambled_exp)

ggplot(vars, aes(delta_phmm_score, delta_expression)) + geom_point()
```

```{r}
cor.test(log(vars$delta_expression), vars$delta_phmm_score)
```

Correlation is better with log.

Let's wrap this all into one function that can be executed on data grouped by TSS name

```{r}
phmms <- list(crp_phmm)

data <- data %>% 
    rowwise() %>% 
    mutate(total_crp_phmm_score = unlist(scan_phmms(variant, 
                                                    phmms = phmms, 
                                                    score_type = 'sum'))) %>% 
    ungroup()

# calculate difference between scramble and wild-type
data <- data %>% 
    group_by(tss_name) %>% 
    mutate(wt_total_crp_phmm_score = ifelse(any(category == 'unscramble'),
                                            total_crp_phmm_score[category == 'unscramble'],
                                            NA),
           delta_phmm_score = total_crp_phmm_score - wt_total_crp_phmm_score) %>% 
    ungroup()

data <- data %>% 
    mutate(delta_expression = RNA_exp_ave - unscrambled_exp)
```

```{r}
ggplot(data, aes(delta_phmm_score, delta_expression)) + geom_point(alpha = 0.25)
```

```{r}
cor.test(data$delta_expression, data$delta_phmm_score)
```

What if we looked at the difference in the log transformed expression?
```{r}
tmp <- data %>% 
    mutate(log_exp = log(RNA_exp_ave),
           wt_log_exp = log(unscrambled_exp),
           delta_log_exp = log_exp - wt_log_exp)

cor.test(tmp$delta_log_exp, tmp$delta_phmm_score)
```

Hmm, interesting the correlation does improve and is significant now, even though it's really small.

```{r}
ggplot(data, aes(as.character(scramble_start), delta_phmm_score)) + geom_boxplot() +
    labs(x = 'scramble start position', y = 'change in CRP score') + 
    theme(axis.text.x = element_text(angle = 45, hjust = 1))
```

```{r}
data %>% 
    filter(category == 'scramble') %>% 
    select(scramble_start, delta_phmm_score, delta_expression) %>% 
    lm(delta_expression ~ . , data = .) %>% 
    summary()
```

```{r}
data %>% 
    filter(category == 'scramble') %>% 
    mutate(log_exp = log(RNA_exp_ave),
           wt_log_exp = log(unscrambled_exp),
           delta_log_exp = log_exp - wt_log_exp) %>% 
    select(scramble_start, delta_phmm_score, delta_log_exp) %>% 
    lm(delta_log_exp ~ . , data = .) %>% 
    summary()
```

Model is marginally better using log transformed data, which is interesting.

```{r, echo = F}
# cleanup
rm(decreased_set, increased_set, kmer_counts, model_tf_subset)
rm(model_all_kmers, model_signif_kmers)
```

Let's find the location of the best CRP match for each wild-type sequence.

```{r}
wt_sequences <- as.list(filter(data, category == 'unscramble') %>% .$variant)
wt_phmm_hits <- lapply(wt_sequences, scan_phmms, phmms = phmms, score_type = 'max')
# unlist the sublists
wt_phmm_hits <- lapply(wt_phmm_hits, unlist)
```

Now that we know where the best CRP site is for each WT, let's create a new data frame
that lists, for each WT sequence, the scrambled variants that overlap the site and the change
in expression between WT and scrambled.

```{r}
# source("http://bioconductor.org/biocLite.R")
# biocLite("IRanges")
library(IRanges)

wt_df <- left_join(data, 
                   data.frame(tss_name = filter(data, category == 'unscramble') %>% .$tss_name, 
                              wt_best_crp_score = unlist(lapply(wt_phmm_hits, `[[`, 1)),
                              wt_best_crp_score_pos = unlist(lapply(wt_phmm_hits, `[[`, 2))),
                   by = 'tss_name')

# overlap <- function(x, start, stop) {
#     if(any(is.na(c(x, start, stop)))) {
#         return(FALSE)
#     }
#     if( (start <= x) & (x <= stop) ) {
#         return(TRUE)
#     }
#     else { return(FALSE) }
# }

overlap <- function(start1, width, start2, stop2, overlap_fraction) {
    if(any(is.na(c(start1, start2, stop2)))) { return(FALSE) }
    min_overlap <- floor(overlap_fraction * width)
    range1 <- IRanges(start = start1, width = width)
    range2 <- IRanges(start = start2, end = stop2)
    common <- findOverlaps(range1, range2, minoverlap = min_overlap)
    if(length(common) != 0) {
        return(TRUE)
    }
    else {
        return(FALSE)
    }
}


# check if scramble overlaps with best CRP site
wt_df <- wt_df %>% 
    rowwise() %>% 
    mutate(overlap_best_crp = ifelse(category == 'scramble',
                                     overlap(wt_best_crp_score_pos, 
                                             crp_phmm$size,
                                             scramble_start + 1, 
                                             scramble_end,
                                             0.3),
                                     TRUE)) %>% 
    ungroup()

# only keep ones that overlap
wt_df <- wt_df %>% 
    filter(overlap_best_crp == T) %>% 
    arrange(tss_name, scramble_start) %>% 
    mutate(log_exp = log(RNA_exp_ave),
           wt_log_exp = log(unscrambled_exp),
           delta_log_exp = log_exp - wt_log_exp)
```


```{r}
# assign position relative to TSS and with respect to strand
wt_df <- wt_df %>% 
    mutate(wt_best_crp_score_pos_relative = case_when(.$strand == '+' ~ wt_best_crp_score_pos - 121,
                                                      .$strand == '-' ~ 150 - wt_best_crp_score_pos - 120,
                                                      TRUE ~ NaN))
```

```{r}
ggplot(wt_df, aes(factor(wt_best_crp_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 8)) +
    labs(x = 'start position of best WT CRP site',
         y = 'log expression scramble - \n log expression WT')
```

```{r}
cor.test(wt_df$wt_best_crp_score_pos_relative, wt_df$delta_log_exp)
```

Not all of the WT sequences are actually regulated by CRP and could be contributing noise.
Let's assign a significance to each CRP score and filter out sequences that do not have
strong sites. Let's take a random sample of the genome and plot the distribution of CRP HMM scores.

```{bash}
bedtools random -l 22 -n 10000 -seed 123 -g ../../ref/Escherichia_coli_K-12_MG1655_genomeFile.txt > ecoli_genome_random_22bp.bed
bedtools getfasta -fi ../../ref/Escherichia_coli_K-12_MG1655.fasta -bed ecoli_genome_random_22bp.bed -fo ecoli_genome_random_22bp.txt -tab -s
```

```{r}
genome_random <- read.table('ecoli_genome_random_22bp.txt', header = F,
                            col.names = c('name', 'sequence'))
random_sequences <- strsplit(genome_random$sequence, '')
random_phmm_hits <- lapply(random_sequences, forward, x = crp_phmm)
# extract just score
random_phmm_hits <- unlist(lapply(random_phmm_hits, `[[`, 1))
```

```{r}
ggplot(data.frame(score = random_phmm_hits), aes(score)) + geom_density() +
    labs(x = 'CRP HMM score', title = '100,000 random genomic sequences 22bp')
```

Calculate permutation p-value: B / m
B : how many observations from the random genomic distribution have a value at least as extreme 
m: number of tests

This can also be thought of as 1 - percentile. Example, 20% percentile is value below which
20% of observations may be found.

```{r}
random_hits_ecdf <- ecdf(random_phmm_hits)
wt_df <- wt_df %>% 
    mutate(emp_pval = 1 - random_hits_ecdf(wt_best_crp_score))
```

```{r}
ggplot(wt_df, aes(wt_best_crp_score)) + geom_density()
```

```{r}
ggplot(wt_df, aes(emp_pval)) + geom_density() + 
    geom_vline(xintercept = 0.05, color = 'red')
```

It seems like the distribution of CRP scores for our library is much different than the genomic distribution.
Maybe promoters in general are more likely to have at least one high scoring CRP site compared to random
genomic sequence (which would fall in genes too). So, most of these WT sequences would have a significant CRP site
with this current "null" genomic distribution. Or, maybe scanning the 150bp chunks with the 22bp HMM is just much more sampling,
so more likely to get a higher score. Let's grab 150bp random chunks from the genome and
see if it changes anything.

```{bash}
bedtools random -l 150 -n 10000 -seed 123 -g ../../ref/Escherichia_coli_K-12_MG1655_genomeFile.txt > ecoli_genome_random_150bp.bed
bedtools getfasta -fi ../../ref/Escherichia_coli_K-12_MG1655.fasta -bed ecoli_genome_random_150bp.bed -fo ecoli_genome_random_150bp.txt -tab -s
```

```{r}
genome_random150 <- read.table('ecoli_genome_random_150bp.txt', header = F,
                            col.names = c('name', 'sequence'))
random150_sequences <- as.list(genome_random150$sequence)
random150_phmm_hits <- lapply(random150_sequences, scan_phmms, phmms = phmms, score_type = 'max')
# unlist
random150_phmm_hits <- lapply(random150_phmm_hits, `[[`, 1)
random150_phmm_hits_score <- unlist(lapply(random150_phmm_hits, `[[`, 1))
```

```{r}
ggplot(data.frame(score = random150_phmm_hits_score), aes(score)) + geom_density() +
    labs(x = 'CRP HMM score', title = '100,000 random genomic sequences 150bp') +
    geom_density(data = wt_df, aes(wt_best_crp_score), color = 'red')
```

```{r}
random_hits_ecdf <- ecdf(random150_phmm_hits_score)
wt_df <- wt_df %>% 
    mutate(emp_pval = 1 - random_hits_ecdf(wt_best_crp_score))
```

```{r}
ggplot(wt_df, aes(emp_pval)) + geom_density() + 
    geom_vline(xintercept = 0.05, color = 'red')
```

Much better!

```{r}
wt_df_crp <- filter(wt_df, emp_pval <= .05)
table(wt_df_crp$category)
```

```{r}
table(data$category)
```

About 15% of WT (unscrambled) sequences contain a CRP site with an empirical 
p-value of 0.05.

Let's look at the start position of the WT best CRP score vs. change in logged expression for only
the WTs (and their overlapping scrambled variants) with significant CRP sites.

```{r}
ggplot(wt_df_crp, aes(factor(wt_best_crp_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 10)) +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    labs(x = 'start position of best WT CRP site',
         y = 'log expression scramble - \n log expression WT',
         title = 'WT with significant CRP site')
```


```{r}
wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp),
              n = n()) %>% 
    ggplot(aes(score_fact, mean_delta)) + geom_bar(stat = 'identity') +
    theme(axis.text.x = element_text(angle = 90, size = 10)) +
    labs(x = 'start position of best WT CRP site',
         y = 'mean(log expression scramble - \n log expression WT)')
```


```{r}
wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact))) %>% 
    ggplot(aes(pos, mean_delta)) + geom_point() + 
    # geom_smooth(span = 0.1) + 
    geom_line() +
    geom_hline(yintercept = 0, linetype = 'dashed')
```

Let's get the mean change in log expression at each position, before we filter out for CRP
significance. Then, we can normalize to this number to account for any positions that
are sensitive to scrambling in general.

```{r}
wt_df_mean_pos <- wt_df %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta_all = mean(delta_log_exp))

wt_df_crp_mean_pos <- wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp))

wt_df_mean_pos_all <- full_join(wt_df_mean_pos, wt_df_crp_mean_pos, by = 'score_fact') %>% 
    mutate(mean_delta_norm = mean_delta - mean_delta_all,
           score_fact = factor(score_fact))
```

```{r}
ggplot(wt_df_mean_pos_all, aes(reorder(score_fact, sort(as.numeric(score_fact))), mean_delta_norm)) + geom_bar(stat = 'identity') +
    theme(axis.text.x = element_text(angle = 90, size = 10)) +
    labs(x = 'start position of best WT CRP site',
         y = 'normalized mean(log expression scramble - \n log expression WT)')
```
 
 Looks almost the same, even after subtracting the average expression change for all WT sequences
 (including those that didn't pass CRP filter).
 
 
 Let's put all of this functionality in one place, so we can generate these graphs for
 a TF of our choice. 
 
```{r}
score_tf_phmm <- function(tf, tf_sites, df, random150_sequences) {
    
    sites_raw <- filter(tf_sites, tf_name == tf, tfbs_sequence != '') %>% .$tfbs_sequence
    sites <- lapply(sites_raw, extract_upper, toString = F)
    # filter sites so they are all one length
    site_lengths <- unlist(lapply(sites, function(x) length(x)))
    major_length <- as.numeric(names(sort(table(site_lengths), decreasing=T))[1])
    sites_filtered <- sites[unlist(lapply(sites, function(x) length(x) == major_length))]
    phmm <- derivePHMM(sites_filtered, k = 5)
    
    wt_sequences <- as.list(filter(df, category == 'unscramble') %>% .$variant)
    wt_phmm_hits <- lapply(wt_sequences, scan_phmms, phmms = list(phmm), score_type = 'max')
    # unlist the sublists
    wt_phmm_hits <- lapply(wt_phmm_hits, unlist)
    
    # create new copy of df with just WT information and corresponding scrambles
    wt_df <- left_join(df, 
                   data.frame(tss_name = filter(df, category == 'unscramble') %>% .$tss_name, 
                              wt_best_tf_score = unlist(lapply(wt_phmm_hits, `[[`, 1)),
                              wt_best_tf_score_pos = unlist(lapply(wt_phmm_hits, `[[`, 2))),
                   by = 'tss_name')
    
        
    # get genomic distribution of PHMM hits
    random150_phmm_hits <- lapply(random150_sequences, scan_phmms, 
                                  phmms = list(phmm), score_type = 'max')
    # unlist
    random150_phmm_hits <- lapply(random150_phmm_hits, `[[`, 1)
    random150_phmm_hits_score <- unlist(lapply(random150_phmm_hits, `[[`, 1))
    random_hits_ecdf <- ecdf(random150_phmm_hits_score)
    
    num_all_hits <- length(sites_raw)
    # only keep WT with significant TF hit
    wt_df <- wt_df %>% 
        mutate(emp_pval = 1 - random_hits_ecdf(wt_best_tf_score)) %>% 
        filter(emp_pval <= 0.05)
    num_sig_hits <- nrow(wt_df)
    
    print(paste("All TF hits in WT:", num_all_hits))
    print(paste("All significant TF hits in WT:", num_sig_hits))
    
    # check if scramble overlaps with best TF site
    wt_df <- wt_df %>% 
        rowwise() %>% 
        mutate(overlap_best_tf = ifelse(category == 'scramble',
                                         overlap(wt_best_tf_score_pos, 
                                                 phmm$size,
                                                 scramble_start + 1, 
                                                 scramble_end,
                                                 0.3),
                                         TRUE)) %>% 
        ungroup()

    # only keep ones that overlap
    wt_df <- wt_df %>% 
        filter(overlap_best_tf == T) %>% 
        arrange(tss_name, scramble_start) %>% 
        mutate(log_exp = log(RNA_exp_ave),
               wt_log_exp = log(unscrambled_exp),
               delta_log_exp = log_exp - wt_log_exp)
    
    # assign position relative to TSS and with respect to strand
    wt_df <- wt_df %>% 
        mutate(wt_best_tf_score_pos_relative = case_when(.$strand == '+' ~ wt_best_tf_score_pos - 121,
                                                          .$strand == '-' ~ 150 - wt_best_tf_score_pos - 120,
                                                          TRUE ~ NaN))
    
    return(wt_df)
}
```


```{r}
tf <- 'Fis'
wt_df_fis <- score_tf_phmm(tf, tf_sites, data, random150_sequences)

ggplot(wt_df_fis, aes(factor(wt_best_tf_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 8)) +
    labs(x = paste('start position of best WT', tf, 'site'),
         y = 'log expression scramble - \n log expression WT')
```


```{r}
wt_df_fis %>% 
    mutate(score_fact = factor(wt_best_tf_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact))) %>% 
    ggplot(aes(pos, mean_delta)) + geom_point() + 
    # geom_smooth(span = 0.1) + 
    geom_line() +
    geom_hline(yintercept = 0, linetype = 'dashed')
```

```{r}
crp_mean_line <- wt_df_crp %>% 
    mutate(score_fact = factor(wt_best_crp_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact)))

fis_mean_line <- wt_df_fis %>% 
    mutate(score_fact = factor(wt_best_tf_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact)))


ggplot(aes(pos, mean_delta), data=crp_mean_line) + geom_point() + 
    # geom_smooth(span = 0.1) + 
    geom_line() +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    geom_line(aes(pos, mean_delta), data=fis_mean_line, color='blue') +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'log expression scramble - \n log expression WT')
```

```{r}
ggplot(aes(pos, mean_delta), data=crp_mean_line) + 
    geom_smooth(span = 0.1, color='black') +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'mean log expression scramble - \n log expression WT',
         title = 'WT with significant CRP site')
```


```{r}
ggplot(aes(pos, mean_delta), data=crp_mean_line) + 
    geom_smooth(span = 0.1, color='black') +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    geom_smooth(aes(pos, mean_delta), data=fis_mean_line, color='blue', span=0.1) +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'mean log expression scramble - \n log expression WT')
```


```{r}
tf <- 'ArcA'
wt_df_arca <- score_tf_phmm(tf, tf_sites, data, random150_sequences)

ggplot(wt_df_arca, aes(factor(wt_best_tf_score_pos_relative), delta_log_exp)) + geom_boxplot() +
    theme(axis.text.x = element_text(angle = 90, size = 8)) +
    labs(x = paste('start position of best WT', tf, 'site'),
         y = 'log expression scramble - \n log expression WT')
```

```{r}
arca_mean_line <- wt_df_arca %>% 
    mutate(score_fact = factor(wt_best_tf_score_pos_relative)) %>% 
    group_by(score_fact) %>% 
    summarise(mean_delta = mean(delta_log_exp)) %>% 
    mutate(pos = as.numeric(levels(score_fact)))

ggplot(aes(pos, mean_delta), data=fis_mean_line)  + 
    geom_smooth(span = 0.1, color='blue') +
    geom_hline(yintercept = 0, linetype = 'dashed') +
    geom_smooth(aes(pos, mean_delta), data=arca_mean_line, color='red', span=0.1) +
    scale_x_continuous(breaks=seq(-120, 30, 10)) +
    geom_vline(xintercept = seq(-120, 30, 10), linetype='dashed') +
    labs(x = 'position relative to TSS',
         y = 'log expression scramble - \n log expression WT')
```



